Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 583963..585108 Replicon chromosome
Accession NZ_CP047422
Organism Shewanella algae strain 18064-CSB-B-B

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag GM320_RS03475 Protein ID WP_054744620.1
Coordinates 583963..584709 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A7X5Z3H2
Locus tag GM320_RS03480 Protein ID WP_025011540.1
Coordinates 584746..585108 (-) Length 121 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GM320_RS03450 579181..579747 - 567 WP_025011535.1 hypoxanthine phosphoribosyltransferase -
GM320_RS03455 580158..580883 + 726 WP_096142385.1 basic amino acid ABC transporter substrate-binding protein -
GM320_RS03460 580890..581567 + 678 WP_044733837.1 amino acid ABC transporter permease -
GM320_RS03465 581560..582285 + 726 WP_025886969.1 amino acid ABC transporter ATP-binding protein -
GM320_RS03470 582384..583949 + 1566 WP_159352397.1 hypothetical protein -
GM320_RS03475 583963..584709 - 747 WP_054744620.1 RES family NAD+ phosphorylase Toxin
GM320_RS03480 584746..585108 - 363 WP_025011540.1 MbcA/ParS/Xre antitoxin family protein Antitoxin
GM320_RS03485 585341..585994 + 654 WP_045283714.1 oxygen-insensitive NAD(P)H-dependent nitroreductase NfsB -
GM320_RS03490 586125..586766 + 642 WP_028780153.1 DnaJ domain-containing protein -
GM320_RS03495 586907..587644 + 738 WP_045283713.1 DsbA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(55-205)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-118)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 28870.61 Da        Isoelectric Point: 4.6112

>T146200 WP_054744620.1 NZ_CP047422:c584709-583963 [Shewanella algae]
MDFSALEPQDFFPRPYLGRGYRLVESQEEAATLSLVDDFDEQMLLESLLDEVKPPYRSGTEHLHYLLKTPFRYPPLRHGS
RFGSITMESFFYASESWQTCLAEVAYYRFVFMADMLEPYLEPLRSEHMLYSVDINARDCADLTLLQGQEVQQQLTHKSNY
TYTQAMGAWLLQQQAQMIRYTSARAEEGVNLALHDPLVLQSTEPQECEYWICQSSADKVAFSRRNSRSMPLTWFLKDFLQ
DGQLPRPA

Download         Length: 747 bp

>T146200 NZ_CP062729:c3570245-3570090 [Escherichia coli O157:H7]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAGTCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 13125.14 Da        Isoelectric Point: 10.4675

>AT146200 WP_025011540.1 NZ_CP047422:c585108-584746 [Shewanella algae]
MNTLEKANAAEVLFKAFSNACSELQLTQAEASRIIGVNPSTLSRNSGKGFKPDSKQGELQLQLIRLYRSLYAIAGGEKAF
MRHWLNSPNKALNGTPKTLLQTVVGLVSVNQYLDAMRGKV

Download         Length: 363 bp

>AT146200 NZ_CP062729:3570257-3570315 [Escherichia coli O157:H7]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7X5Z3H2

References