Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 582292..582910 Replicon chromosome
Accession NZ_CP047405
Organism Escherichia coli strain MS6193

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag MS6193_RS02795 Protein ID WP_001291435.1
Coordinates 582292..582510 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag MS6193_RS02800 Protein ID WP_000344800.1
Coordinates 582536..582910 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MS6193_RS02760 577582..578154 + 573 WP_000779826.1 lipoprotein -
MS6193_RS02765 578185..578496 - 312 WP_000409911.1 MGMT family protein -
MS6193_RS02775 578875..579228 + 354 WP_000878141.1 DUF1428 family protein -
MS6193_RS02780 579270..580820 - 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
MS6193_RS02785 580984..581454 - 471 WP_000136192.1 YlaC family protein -
MS6193_RS02790 581570..582121 - 552 WP_000102564.1 maltose O-acetyltransferase -
MS6193_RS02795 582292..582510 - 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
MS6193_RS02800 582536..582910 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
MS6193_RS02805 583456..586605 - 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
MS6193_RS02810 586628..587821 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T146155 WP_001291435.1 NZ_CP047405:c582510-582292 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T146155 NZ_CP062727:283385-283492 [Escherichia coli O157:H7]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT146155 WP_000344800.1 NZ_CP047405:c582910-582536 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT146155 NZ_CP062727:c283337-283271 [Escherichia coli O157:H7]
GGTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References