Detailed information of TA system TA146149

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4163110..4163779
• Replicon: chromosome
• Accession: NZ_CP047391
• Organism: Serratia marcescens strain 1602

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A2V4FX75
• Locus tag: GRX59_RS19735
• Protein ID: WP_033649453.1
• Coordinates: 4163110..4163532 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A8G2G4M4
• Locus tag: GRX59_RS19740
• Protein ID: WP_004931679.1
• Coordinates: 4163513..4163779 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GRX59_RS19715	4158999..4159517	+	519	WP_033635825.1	flavodoxin FldB	-
GRX59_RS19720	4159555..4160919	-	1365	WP_041036554.1	cell envelope integrity protein CreD	-
GRX59_RS19725	4161000..4162418	-	1419	WP_033649455.1	two-component system sensor histidine kinase CreC	-
GRX59_RS19730	4162415..4163110	-	696	WP_033649454.1	two-component system response regulator CreB	-
GRX59_RS19735	4163110..4163532	-	423	WP_033649453.1	protein YgfX	Toxin
GRX59_RS19740	4163513..4163779	-	267	WP_004931679.1	FAD assembly factor SdhE	Antitoxin
GRX59_RS19745	4164100..4165092	+	993	WP_033649452.1	tRNA-modifying protein YgfZ	-
GRX59_RS19750	4165131..4165628	-	498	WP_033649451.1	DUF2165 domain-containing protein	-
GRX59_RS19755	4165779..4166453	-	675	WP_033649450.1	hemolysin III family protein	-
GRX59_RS19760	4166637..4167245	+	609	WP_025304127.1	HD domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16471.59 Da
• Isoelectric Point: 10.8114

>T146149 WP_033649453.1 NZ_CP047391:c4163532-4163110 [Serratia marcescens]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGFGPLWLVLLTLVVFQCIRSQKRIAAAQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGMLLTLLPMEGKKRRRLWLASDCMSKEEWRHLRQLLLYPPAGDGEDP

Nucleotide

• Length: 423 bp

>T146149 NZ_CP062725:4900206-4900547 [Escherichia coli O157:H7]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10387.89 Da
• Isoelectric Point: 4.7921

>AT146149 WP_004931679.1 NZ_CP047391:c4163779-4163513 [Serratia marcescens]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDGELQRMVTLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT146149 NZ_CP062725:c4900211-4900135 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: A0A2V4FX75