Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1697523..1698048 Replicon chromosome
Accession NZ_CP047391
Organism Serratia marcescens strain 1602

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag GRX59_RS08030 Protein ID WP_041034302.1
Coordinates 1697523..1697807 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A8B4GIN1
Locus tag GRX59_RS08035 Protein ID WP_004928423.1
Coordinates 1697797..1698048 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GRX59_RS08005 1692783..1693916 + 1134 WP_033637812.1 putrescine ABC transporter ATP-binding subunit PotG -
GRX59_RS08010 1693941..1694903 + 963 WP_033646669.1 putrescine ABC transporter permease PotH -
GRX59_RS08015 1694900..1695745 + 846 WP_016928360.1 putrescine ABC transporter permease PotI -
GRX59_RS08020 1695850..1696329 + 480 WP_049197168.1 YbjO family protein -
GRX59_RS08025 1696399..1697526 + 1128 WP_060438093.1 23S rRNA (uracil(747)-C(5))-methyltransferase RlmC -
GRX59_RS08030 1697523..1697807 - 285 WP_041034302.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GRX59_RS08035 1697797..1698048 - 252 WP_004928423.1 prevent-host-death protein Antitoxin
GRX59_RS08040 1698150..1698884 - 735 WP_033637816.1 arginine ABC transporter substrate-binding protein -
GRX59_RS08045 1699084..1699752 - 669 WP_033637817.1 arginine ABC transporter permease ArtM -
GRX59_RS08050 1699752..1700468 - 717 WP_033637818.1 arginine ABC transporter permease ArtQ -
GRX59_RS08055 1700478..1701209 - 732 WP_033637819.1 arginine ABC transporter substrate-binding protein -
GRX59_RS08060 1701242..1701970 - 729 WP_038884338.1 arginine ABC transporter ATP-binding protein ArtP -
GRX59_RS08065 1702235..1702777 - 543 WP_033637821.1 lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10798.92 Da        Isoelectric Point: 10.5850

>T146136 WP_041034302.1 NZ_CP047391:c1697807-1697523 [Serratia marcescens]
MTYKLEFEEHALKEFKKLSPVIREQFKKKLVSVLVNPHVPANKLAGLPDCYKIKLRASGFRLVYRVMETEIVVLVLSVGK
REHSAAYTAAKKRL

Download         Length: 285 bp

>T146136 NZ_CP062725:2318216-2318319 [Escherichia coli O157:H7]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTTTTTTT

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9108.39 Da        Isoelectric Point: 4.5203

>AT146136 WP_004928423.1 NZ_CP047391:c1698048-1697797 [Serratia marcescens]
MTVQPILADSAVSISDFKKSPNAALKEAQGQPVAVLTNGKISGYYVSPETWEAIAEYLEDIELAEIVRSRMNGKRIKVNL
DDL

Download         Length: 252 bp

>AT146136 NZ_CP062725:c2318320-2318086 [Escherichia coli O157:H7]
TAAAAAAAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCA
TTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAAT
AAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCGTTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4GIN1

References