Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1074312..1074933 Replicon chromosome
Accession NZ_CP047391
Organism Serratia marcescens strain 1602

Toxin (Protein)


Gene name Hha Uniprot ID A0A8B4G7F9
Locus tag GRX59_RS05020 Protein ID WP_004940313.1
Coordinates 1074312..1074515 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2X2G5J9
Locus tag GRX59_RS05025 Protein ID WP_004940312.1
Coordinates 1074565..1074933 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GRX59_RS04995 1070103..1070549 + 447 WP_039566985.1 type II secretion system protein M -
GRX59_RS05000 1070586..1071401 + 816 WP_049235196.1 A24 family peptidase -
GRX59_RS05005 1071398..1071760 - 363 WP_033647278.1 type II secretion system pilot lipoprotein GspS -
GRX59_RS05010 1072014..1073444 + 1431 WP_060445687.1 N-acetylglucosamine-binding protein GbpA -
GRX59_RS05015 1073497..1074015 + 519 WP_033647275.1 cytochrome b/b6 domain-containing protein -
GRX59_RS05020 1074312..1074515 - 204 WP_004940313.1 hemolysin expression modulator Hha Toxin
GRX59_RS05025 1074565..1074933 - 369 WP_004940312.1 Hha toxicity modulator TomB Antitoxin
GRX59_RS05030 1075092..1075445 - 354 WP_033647274.1 hypothetical protein -
GRX59_RS05035 1075853..1076566 + 714 WP_033647273.1 ABC transporter ATP-binding protein -
GRX59_RS05040 1076563..1077420 + 858 WP_033637343.1 metal ABC transporter permease -
GRX59_RS05045 1077446..1078324 + 879 WP_041033680.1 metal ABC transporter substrate-binding protein -
GRX59_RS05050 1078431..1078571 - 141 WP_004940304.1 type B 50S ribosomal protein L36 -
GRX59_RS05055 1078584..1078838 - 255 WP_004940303.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8107.37 Da        Isoelectric Point: 6.9756

>T146134 WP_004940313.1 NZ_CP047391:c1074515-1074312 [Serratia marcescens]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Download         Length: 204 bp

>T146134 NZ_CP062725:946470-946877 [Escherichia coli O157:H7]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14261.95 Da        Isoelectric Point: 4.4314

>AT146134 WP_004940312.1 NZ_CP047391:c1074933-1074565 [Serratia marcescens]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT

Download         Length: 369 bp

>AT146134 NZ_CP062725:946223-946489 [Escherichia coli O157:H7]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTATGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCCGATC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4G7F9

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2G5J9

References