Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/CC2985(antitoxin)
Location 506755..507299 Replicon chromosome
Accession NZ_CP047387
Organism Agrobacterium sp. CGMCC 11546

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag GSF67_RS02575 Protein ID WP_006309849.1
Coordinates 507009..507299 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A7I0REI2
Locus tag GSF67_RS02570 Protein ID WP_006309847.1
Coordinates 506755..507006 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GSF67_RS02545 502518..503198 + 681 WP_006309842.1 GntR family transcriptional regulator -
GSF67_RS02550 503244..503717 + 474 WP_006309843.1 DUF1284 domain-containing protein -
GSF67_RS02555 503895..504995 - 1101 WP_006309844.1 hypothetical protein -
GSF67_RS02560 505231..506376 + 1146 WP_006309845.1 site-specific DNA-methyltransferase -
GSF67_RS02565 506610..506765 - 156 WP_006309848.1 hypothetical protein -
GSF67_RS02570 506755..507006 + 252 WP_006309847.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
GSF67_RS02575 507009..507299 + 291 WP_006309849.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GSF67_RS02580 507333..507944 - 612 WP_006309850.1 HAD family phosphatase -
GSF67_RS02585 507941..509044 - 1104 WP_006309851.1 A/G-specific adenine glycosylase -
GSF67_RS02590 509143..509670 + 528 WP_006309852.1 DUF721 domain-containing protein -
GSF67_RS02595 509799..510479 + 681 WP_006309853.1 DsbA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin

Antitoxin ParD

(3-63)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11192.83 Da        Isoelectric Point: 5.1737

>T146130 WP_006309849.1 NZ_CP047387:507009-507299 [Agrobacterium sp. CGMCC 11546]
MGFRLSLLAEEDVIRIAEEGILIFGAKQAQKYHQELFAIFELISCSPRMARERDELSPPLRIQRFKAHLVVYSVDADDEV
FIVRVRHGHEDWVNEP

Download         Length: 291 bp

>T146130 NZ_CP062725:431608-432582 [Escherichia coli O157:H7]
GTGGGGCGTGCCGGTCGCGGTATCGATTCTGCTGTTGGCATACTGCTTTGCGGCAGTGAAGACCGTGCTATTCATAAATT
CTTCCGTGAAAGCGCCTTTCCTGCGGAGGCGCAAATTCATGAAATACTCAACGTACTTAGCGTGAATGACGGTCTTACCT
TACGAGGCATTGAACAACGGACGAATCTCCGTTATGGGCAAATAGAAAAAGCACTGAAATTATTGGTAGCTGAAAATCCA
TCGCCTGTGGTGTATACCGAGAAATTATGGCGCAGAACAATTGTCAGTTTTTCTCCTGACCATGAACGAATTAACCATTT
GATGAATCAGAGAAAAAGTGAGCTGGCAGACGTTGAAAGCTATATCACGACCAAGGAGTGCAAAATGCAATTTCTGCGCC
GCGCACTCGATGAGCCAGGTGCCGAACATTGTGGTAAATGTAGCAGTTGTCTTCAGCATCCGTTGTTGTCGCCCGACATT
GATAGCGGCTTACTCCATGCGGCAAACTTATTTATTAAACACGCTGACCTGTCATTAAATCTCAATAAACAGGTGGCAGC
TGGGGCTTTTACGCAATACGGATTTAAAGGGAACTTGCCTGCGAGTTTACAAGGATCTACGGGGCGAATCCTTTCTCGTT
GGGGATATTCCGGGTGGGGAAAGCAGGTAGCACAGGAGAAAAAAACGGGGCGATTCAGTGATGAACTGGTGGAGGCATGT
GCGGAAATGGTTCGCCAACGCTGGAATCCGCATCCTGAACCAACCTGGGTATGCTGCGTTCCTTCATTAAAGCACCTCGA
CCTGGTTCCTGATTTTGAAAGCACCTCGACCTGGTTCCTGATTTTGCCCGGCGACTGGCGGCGAAACTTGGCTTACCTTT
TATTGATGCCATTGAAAAAGTCGTGGACAATCCACCGCAGAAAATGCAGCAAAACCGTTTCCACCAGTGTCAAAATCTCG
ACGGGGCGTTTGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9327.47 Da        Isoelectric Point: 4.8537

>AT146130 WP_006309847.1 NZ_CP047387:506755-507006 [Agrobacterium sp. CGMCC 11546]
MVTMNISLPEPMKEWVEAQSKTGRYSNASDYVRDLIRRDQERGEKIAAMQRLVDEGLQSGIGDRSPEALFAEAEARSAKR
DIG

Download         Length: 252 bp

>AT146130 NZ_CP062725:432641-433936 [Escherichia coli O157:H7]
ATGGACGCTGACAGTTCTAACAGCACTGTTACGCCAGGCAGGTTGCCCGACGGTTTATCCTCTTGCCCTTGCTTCTACCT
CGGTAAAAAATTGATGAATCTTTCAGCCAATGCACAAGCAACTCTCCTGCTAACCAGCGATTTTTCTCGCGCGGCGGCGA
GTAAGTATAAACCTCTTAGTAATAGTGAATGGGGGAAGTTTGCATTATGGCTGAAGCACCAACGTATCAGTCCCGCCGAG
CTTCTGGTGCCGCAACCGCAAGAGAAACTTACAGGCTGGAGCGATCCGCGTATTTCTCAGGAGCGTATTCTTGGCTTGCT
GGCGCGTGGTCATAGTCTGGCGTTGGCGGTAGATAAGTGGCAACGCGCCGGTTTATGGATCTTAACCCGCGGAGATGCTG
ATTATCCCGTTCGCTTGAAAAACCGATTGCGAACGGATGCACCTCCCGTTTTATTTGGCTGCGGGAATAAAGCATTACTG
CAAGCGGAAGGTATGGCGATTGTTGGCTCGCGAGATGCTCCGACTGACGATTTGCGCTATACCCAACAACTGGCCGCGAA
ACTGGCCCAACAGGGGATTTGCGTTATCTCTGGTGGTGCGCGAGGTATTGATGAATGTGCAATGGCGTCGGCACTGGAGG
CCGGGGGAACTGCCGTTGGCGTATTAGCTGATAGCTTGTTAAAAACGAGTACGTTAGTGAAATGGCGTGAAGGGCTTATA
GCAGGCAACCTGGTGTTGATTTCGCCGTTTTACCCAGAGGTACGTTTCACCGTCGGCAATGCGATGGCGCGAAATAAATA
TATTTATTGCCTTGCTGAAAGCGCAATGGTTGTACGTGCGGGAATGACCGGTGGAACGATAACCGGGGCGATGGAGGCAT
TAAAACATCAGTGGCTGCCTGTGCAGGTTAAACCAAATCAGGATATGCAATCAGCCAATTCACGATTAGTAGAAAATGGG
GCGTCATGGAGTGCTGAACAGGCTGAGAATGTGACGATCAGACTGCCAGACGTTCCTGGGCTGATGTATGACAGAGCACT
CCGTAACGCTCAACCAGAACTGTTTTCGCTGCATGAAGATGACGCAAATTACGCAGTAATGCCCGCGTATACGCCTGTCG
ATTTTTATCAACTCTTTGTGGCGGAACTGGCGATCCTTGCAAAGGAATCGATAAGTATTGAAAGGCTGGCGTCTTGTACT
GGTTTAACCATCGAACAAATTAGTGTGTGGCTGAACCGCGCAGAAGAAGAGGGAAGGGTTATCCGATTGGGCGAAGGTCA
TTATCAGTTCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7I0REI2

References