146129

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 384471..384957 Replicon chromosome
Accession NZ_CP047387
Organism Agrobacterium sp. CGMCC 11546

Toxin (Protein)


Gene name pasB Uniprot ID A0A7I0RKV8
Locus tag GSF67_RS01950 Protein ID WP_035215419.1
Coordinates 384471..384740 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID A0A7Z7BLB4
Locus tag GSF67_RS01955 Protein ID WP_006313156.1
Coordinates 384724..384957 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GSF67_RS01920 379514..380290 - 777 WP_006313140.1 L,D-transpeptidase -
GSF67_RS01925 380529..381158 + 630 WP_006313142.1 DNA-3-methyladenine glycosylase I -
GSF67_RS01930 381155..381598 + 444 WP_006313144.1 hypothetical protein -
GSF67_RS01935 381624..382667 - 1044 WP_006313145.1 YeiH family protein -
GSF67_RS01940 382749..383666 + 918 WP_006313146.1 LysR family transcriptional regulator -
GSF67_RS01945 383700..384464 - 765 WP_006313147.1 hypothetical protein -
GSF67_RS01950 384471..384740 - 270 WP_035215419.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GSF67_RS01955 384724..384957 - 234 WP_006313156.1 ribbon-helix-helix protein, CopG family Antitoxin
GSF67_RS01960 385114..386637 + 1524 WP_006313157.1 histidine--tRNA ligase -
GSF67_RS01965 386642..387010 + 369 WP_006313158.1 VOC family protein -
GSF67_RS01970 387027..388154 + 1128 WP_006313159.1 ATP phosphoribosyltransferase regulatory subunit -
GSF67_RS01975 388151..388843 + 693 WP_006313160.1 ATP phosphoribosyltransferase -
GSF67_RS01980 388907..389353 - 447 WP_006313161.1 DoxX family protein -
GSF67_RS01985 389509..389943 - 435 WP_006313162.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-88)

Antitoxin

Protein of unknown function DUF6290

(6-73)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10456.01 Da        Isoelectric Point: 10.3398

>T146129 WP_035215419.1 NZ_CP047387:c384740-384471 [Agrobacterium sp. CGMCC 11546]
MIWRIEFQRNAVKQLGKLTKSDANRIVSFLTDRVAQDDNPRRAGAALQGSELGNFWRYRVGDYRIICDIQDHKLVVLVVE
IGHRREIYR

Download         Length: 270 bp

>T146129 NZ_CP062725:408069-408596 [Escherichia coli O157:H7]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATAAATCGCTGGGCTTTATCCCTTTAGTCGGGGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATTGAACTGCTTTTTACACAGAGCGATTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 9223.39 Da        Isoelectric Point: 4.7543

>AT146129 WP_006313156.1 NZ_CP047387:c384957-384724 [Agrobacterium sp. CGMCC 11546]
MSKQTAIRLPDETYERLKALSERTGRTSAYYIREAIEKHIEDMEDLYLAEEAMRKHIANKERTYTLEEVMRDLDLEN

Download         Length: 234 bp

>AT146129 NZ_CP062725:407796-408062 [Escherichia coli O157:H7]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGGGCTGCGGAAGTGATTGAACAGCATCGGCGGG
TGATCCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7I0RKV8

Antitoxin

Source ID Structure
AlphaFold DB A0A7Z7BLB4

References