Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1316026..1316591 Replicon chromosome
Accession NZ_CP047386
Organism Pandoraea fibrosis strain 7641

Toxin (Protein)


Gene name vapC Uniprot ID A0A8T8BJU7
Locus tag PJ20_RS05830 Protein ID WP_039370059.1
Coordinates 1316026..1316397 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A5E4VA17
Locus tag PJ20_RS05835 Protein ID WP_010804388.1
Coordinates 1316394..1316591 (-) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PJ20_RS05810 1311317..1312180 - 864 WP_039370065.1 NAD(P)H-binding protein -
PJ20_RS05815 1312241..1313569 - 1329 WP_052240634.1 FAD-dependent monooxygenase -
PJ20_RS05820 1313687..1314583 + 897 WP_080759167.1 helix-turn-helix transcriptional regulator -
PJ20_RS05825 1314580..1315662 + 1083 WP_039370062.1 NAD(P)/FAD-dependent oxidoreductase -
PJ20_RS05830 1316026..1316397 - 372 WP_039370059.1 type II toxin-antitoxin system VapC family toxin Toxin
PJ20_RS05835 1316394..1316591 - 198 WP_010804388.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
PJ20_RS05840 1316888..1317196 + 309 WP_039370056.1 hypothetical protein -
PJ20_RS05845 1317548..1318255 + 708 WP_039370052.1 phospholipase D family protein -
PJ20_RS05855 1318845..1319729 - 885 WP_039370050.1 NAD(P)-dependent oxidoreductase -
PJ20_RS05860 1319737..1320858 - 1122 WP_052240646.1 ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-112)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-46)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13362.56 Da        Isoelectric Point: 6.8800

>T146127 WP_039370059.1 NZ_CP047386:c1316397-1316026 [Pandoraea fibrosis]
MILVDTSVWIDHLRAGDATLVQLLETGRVLAHPYVIGELALGSLKNRDVVISTLRDLPRVAVATDDEVLRFIGEQTLFGL
GIGYVDAHLLAATRLTPGAAIWTRDKRLAATAERLSLAAKILH

Download         Length: 372 bp

>T146127 NZ_CP062725:283379-283486 [Escherichia coli O157:H7]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7177.21 Da        Isoelectric Point: 6.3084

>AT146127 WP_010804388.1 NZ_CP047386:c1316591-1316394 [Pandoraea fibrosis]
MRTTLALDDELLAKAQAFTGLQEKSALIREALKALIERESARRLARLGGTEADLSDIPRRQTEPA

Download         Length: 198 bp

>AT146127 NZ_CP062725:c283331-283265 [Escherichia coli O157:H7]
GGTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5E4VA17

References