Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1290286..1292137 Replicon chromosome
Accession NZ_CP047386
Organism Pandoraea fibrosis strain 7641

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag PJ20_RS05725 Protein ID WP_052240638.1
Coordinates 1290286..1291194 (+) Length 303 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag PJ20_RS05730 Protein ID WP_080759169.1
Coordinates 1291196..1292137 (+) Length 314 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PJ20_RS05700 1285704..1286780 + 1077 WP_039370229.1 porin -
PJ20_RS05705 1287182..1287955 + 774 WP_039370227.1 ABC transporter ATP-binding protein -
PJ20_RS05710 1287994..1288776 + 783 WP_039370103.1 ABC transporter permease -
PJ20_RS05715 1288795..1289586 + 792 WP_080759170.1 SDR family oxidoreductase -
PJ20_RS05720 1289629..1290186 + 558 WP_039370100.1 cupin domain-containing protein -
PJ20_RS05725 1290286..1291194 + 909 WP_052240638.1 alpha/beta fold hydrolase Toxin
PJ20_RS05730 1291196..1292137 + 942 WP_080759169.1 IclR family transcriptional regulator Antitoxin
PJ20_RS05735 1292134..1292940 + 807 WP_039370097.1 SDR family oxidoreductase -
PJ20_RS05740 1292933..1294585 + 1653 WP_039370096.1 thiamine pyrophosphate-binding protein -
PJ20_RS05745 1294578..1295396 + 819 WP_039370094.1 aspartate dehydrogenase -
PJ20_RS05750 1295410..1296906 + 1497 WP_039370091.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(53-288)

Antitoxin

Transcription regulator IclR, C-terminal

(168-291)


Sequences

Toxin        


Download         Length: 303 a.a.        Molecular weight: 31347.41 Da        Isoelectric Point: 5.0973

>T146126 WP_052240638.1 NZ_CP047386:1290286-1291194 [Pandoraea fibrosis]
MQAEAFPSEVPDDATVAPLCERLNAFPYHTLATRTGTVGYRCSGARTAGGMPVVMLHGIGSGAASWLAQFEATGLDASLY
AWDAPGYGQTSNVADAEPHADVYANALEAWLDALGLERVALVGHSLGAIMATTFASRAPQRVRGLFLCSPAGGYGKADPD
VRVSKRDSRLAMLDKLGPAGMARERSDNLVAPGAADLARAWVKWNMARVQPAGYRQATHLLSNGDVAGELTQYVAANAGP
VAVAVGAQDAITPPAACQTIADVAGVPLQIIEGAGHASYIETPDVLNAALAAWLERIAAGER

Download         Length: 909 bp

>T146126 NZ_CP062724:71578-71736 [Escherichia coli O157:H7]
ATGAAACTACCACGCAGCTCTCTTGTCTGGTGTGTGTTGATAGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGATACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 314 a.a.        Molecular weight: 34057.80 Da        Isoelectric Point: 6.0586

>AT146126 WP_080759169.1 NZ_CP047386:1291196-1292137 [Pandoraea fibrosis]
MAPATPKRAMAVADAQIEDDSPSLQGAQTEGEDLAEGSTSETRYLVPGLERGLRILTQFSPREAVFSAPELSQRLGIPRT
TVFRLLQTLEAMGFLERAGSEKNFRLGVAVLRLGFEYLSSLELTDLGIPIIERLRDATQLTSHIVIRDGRDIVFVAKAQS
VAGVFNSIKVNVGTRLPAHATVHGHVLMGDLTLTELRALYPEKTLEKYTPQTPETLAELFERVREDAERGYAVSASSFER
GISVVSAPVRNDAGRICAAITVTIPRANIDSSMLDAGLIGQVREAADALSHRLNYRPGSDSQPTPYMKSLGLK

Download         Length: 942 bp

>AT146126 NZ_CP062724:71315-71513 [Escherichia coli O157:H7]
TCACACGGATTGCCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAATGTGGTCAGCGTGCTGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAGGA
CAAAAGCCCCGTAGTTAATTTTTCATTAACCCACGAGGC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References