Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 5055145..5056996 Replicon chromosome
Accession NZ_CP047385
Organism Pandoraea fibrosis strain 6399

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag PI93_RS22275 Protein ID WP_052240638.1
Coordinates 5056088..5056996 (-) Length 303 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag PI93_RS22270 Protein ID WP_080759169.1
Coordinates 5055145..5056086 (-) Length 314 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PI93_RS22250 5050376..5051872 - 1497 WP_039370091.1 aldehyde dehydrogenase -
PI93_RS22255 5051886..5052704 - 819 WP_039370094.1 aspartate dehydrogenase -
PI93_RS22260 5052697..5054349 - 1653 WP_039370096.1 thiamine pyrophosphate-binding protein -
PI93_RS22265 5054342..5055148 - 807 WP_039370097.1 SDR family oxidoreductase -
PI93_RS22270 5055145..5056086 - 942 WP_080759169.1 IclR family transcriptional regulator Antitoxin
PI93_RS22275 5056088..5056996 - 909 WP_052240638.1 alpha/beta fold hydrolase Toxin
PI93_RS22280 5057096..5057653 - 558 WP_039370100.1 cupin domain-containing protein -
PI93_RS22285 5057696..5058487 - 792 WP_080759170.1 SDR family oxidoreductase -
PI93_RS22290 5058506..5059288 - 783 WP_039370103.1 ABC transporter permease -
PI93_RS22295 5059327..5060100 - 774 WP_039370227.1 ABC transporter ATP-binding protein -
PI93_RS22300 5060502..5061578 - 1077 WP_039370229.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(53-288)

Antitoxin

Transcription regulator IclR, C-terminal

(168-291)


Sequences

Toxin        


Download         Length: 303 a.a.        Molecular weight: 31347.41 Da        Isoelectric Point: 5.0973

>T146123 WP_052240638.1 NZ_CP047385:c5056996-5056088 [Pandoraea fibrosis]
MQAEAFPSEVPDDATVAPLCERLNAFPYHTLATRTGTVGYRCSGARTAGGMPVVMLHGIGSGAASWLAQFEATGLDASLY
AWDAPGYGQTSNVADAEPHADVYANALEAWLDALGLERVALVGHSLGAIMATTFASRAPQRVRGLFLCSPAGGYGKADPD
VRVSKRDSRLAMLDKLGPAGMARERSDNLVAPGAADLARAWVKWNMARVQPAGYRQATHLLSNGDVAGELTQYVAANAGP
VAVAVGAQDAITPPAACQTIADVAGVPLQIIEGAGHASYIETPDVLNAALAAWLERIAAGER

Download         Length: 909 bp

>T146123 NZ_CP062723:c5059482-5059309 [Escherichia coli O157:H7]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 314 a.a.        Molecular weight: 34057.80 Da        Isoelectric Point: 6.0586

>AT146123 WP_080759169.1 NZ_CP047385:c5056086-5055145 [Pandoraea fibrosis]
MAPATPKRAMAVADAQIEDDSPSLQGAQTEGEDLAEGSTSETRYLVPGLERGLRILTQFSPREAVFSAPELSQRLGIPRT
TVFRLLQTLEAMGFLERAGSEKNFRLGVAVLRLGFEYLSSLELTDLGIPIIERLRDATQLTSHIVIRDGRDIVFVAKAQS
VAGVFNSIKVNVGTRLPAHATVHGHVLMGDLTLTELRALYPEKTLEKYTPQTPETLAELFERVREDAERGYAVSASSFER
GISVVSAPVRNDAGRICAAITVTIPRANIDSSMLDAGLIGQVREAADALSHRLNYRPGSDSQPTPYMKSLGLK

Download         Length: 942 bp

>AT146123 NZ_CP062723:c5059806-5059510 [Escherichia coli O157:H7]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References