Detailed information of TA system TA146121

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 87103..87689
• Replicon: chromosome
• Accession: NZ_CP047385
• Organism: Pandoraea fibrosis strain 6399

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: PI93_RS00320
• Protein ID: WP_080759334.1
• Coordinates: 87435..87689 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A8T8BGV2
• Locus tag: PI93_RS00315
• Protein ID: WP_039373312.1
• Coordinates: 87103..87438 (-)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PI93_RS00300	82377..84920	+	2544	WP_167525559.1	ATP-binding cassette domain-containing protein	-
PI93_RS00305	84917..86575	+	1659	WP_052240877.1	gamma-glutamyltransferase	-
PI93_RS00310	86583..86966	-	384	WP_039373309.1	single-stranded DNA-binding protein	-
PI93_RS00315	87103..87438	-	336	WP_039373312.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
PI93_RS00320	87435..87689	-	255	WP_080759334.1	type II toxin-antitoxin system HicA family toxin	Toxin
PI93_RS00330	88394..90280	-	1887	WP_039373314.1	methyl-accepting chemotaxis protein	-
PI93_RS00335	90507..90965	-	459	WP_039373315.1	low affinity iron permease family protein	-
PI93_RS00340	91044..91673	-	630	WP_039373316.1	ATP-binding cassette domain-containing protein	-
PI93_RS00345	91687..91956	-	270	WP_039373319.1	metal/formaldehyde-sensitive transcriptional repressor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-75)

Antitoxin

• Uncharacterised protein family HicB (55-105)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9417.93 Da
• Isoelectric Point: 10.5567

>T146121 WP_080759334.1 NZ_CP047385:c87689-87435 [Pandoraea fibrosis]
MKSKSRRTLDLIFSRPTPASVKWADVVALFLELGGALSEREGSRVAVYLFDQIKVMHRPHPSPNMDKGAIASIRKWLEDN
GVQP

Nucleotide

• Length: 255 bp

>T146121 NZ_CP062723:4828124-4828465 [Escherichia coli O157:H7]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12054.63 Da
• Isoelectric Point: 5.5687

>AT146121 WP_039373312.1 NZ_CP047385:c87438-87103 [Pandoraea fibrosis]
MNNVMIIGGHKAVISFDPEIDMFRGEFVGLNGGADFYADDVSGLRREGELSLKVFLEECARRGVEPQKQFSGKFVIRLNP
KAHEAAAIAAAAHGQSLNQWVADTLEQAAHA

Nucleotide

• Length: 336 bp

>AT146121 NZ_CP062723:c4828129-4828053 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT