Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 88489..89036 Replicon plasmid pCAU16175_2
Accession NZ_CP047380
Organism Escherichia coli strain CAU16175

Toxin (Protein)


Gene name parE Uniprot ID E9LLH3
Locus tag GTP13_RS30010 Protein ID WP_000969996.1
Coordinates 88489..88770 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag GTP13_RS30015 Protein ID WP_044720349.1
Coordinates 88767..89036 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTP13_RS30005 87660..88354 + 695 WP_085949012.1 IS1 family transposase -
GTP13_RS30010 88489..88770 - 282 WP_000969996.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GTP13_RS30015 88767..89036 - 270 WP_044720349.1 hypothetical protein Antitoxin
GTP13_RS30020 89539..90162 + 624 WP_077150956.1 recombinase family protein -
GTP13_RS30025 90143..93109 + 2967 WP_072024409.1 Tn3 family transposase -
GTP13_RS30030 93135..93359 + 225 Protein_95 transposase -
GTP13_RS30035 93573..93761 + 189 WP_000957857.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - vat / toxB / toxB / espC / espT 1..161176 161176
- inside IScluster/Tn - - 67310..94885 27575


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10893.57 Da        Isoelectric Point: 8.4615

>T146112 WP_000969996.1 NZ_CP047380:c88770-88489 [Escherichia coli]
MMEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YILRVLHTAQKWP

Download         Length: 282 bp

>T146112 NZ_CP062723:3114620-3114727 [Escherichia coli O157:H7]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10263.63 Da        Isoelectric Point: 10.1734

>AT146112 WP_044720349.1 NZ_CP047380:c89036-88767 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDIVESSATAWRD
KMSRKVAGK

Download         Length: 270 bp

>AT146112 NZ_CP062723:c3114567-3114506 [Escherichia coli O157:H7]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E9LLH3

Antitoxin

Source ID Structure

References