Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4732459..4733294 Replicon chromosome
Accession NZ_CP047378
Organism Escherichia coli strain CAU16175

Toxin (Protein)


Gene name yeeV Uniprot ID A0A7W4PV54
Locus tag GTP13_RS24270 Protein ID WP_000854821.1
Coordinates 4732917..4733294 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B7MK11
Locus tag GTP13_RS24265 Protein ID WP_001285610.1
Coordinates 4732459..4732827 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTP13_RS24245 4730185..4731003 + 819 WP_001234702.1 DUF945 domain-containing protein -
GTP13_RS24250 4731094..4731579 + 486 WP_064559960.1 antirestriction protein -
GTP13_RS24255 4731595..4732071 + 477 WP_162008690.1 RadC family protein -
GTP13_RS24260 4732158..4732379 + 222 WP_000692350.1 DUF987 domain-containing protein -
GTP13_RS24265 4732459..4732827 + 369 WP_001285610.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
GTP13_RS24270 4732917..4733294 + 378 WP_000854821.1 type IV toxin-antitoxin system toxin CbtA Toxin
GTP13_RS24275 4733291..4733488 + 198 Protein_4730 hypothetical protein -
GTP13_RS24280 4733516..4733713 + 198 WP_085949090.1 DUF957 domain-containing protein -
GTP13_RS24285 4733798..4734640 + 843 WP_001280493.1 DUF4942 domain-containing protein -
GTP13_RS24290 4734921..4735457 - 537 WP_000942795.1 GspM family type II secretion system protein YghD -
GTP13_RS24295 4735459..4736637 - 1179 WP_000097220.1 type II secretion system protein GspL -
GTP13_RS24300 4736634..4737611 - 978 WP_000633210.1 type II secretion system minor pseudopilin GspK -
GTP13_RS24305 4737608..4738213 - 606 WP_001255030.1 type II secretion system minor pseudopilin GspJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - gspM / gspL / gspK / gspJ / gspI / gspH / gspG / gspF / gspE / gspE / gspD 4687827..4744393 56566


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13930.95 Da        Isoelectric Point: 8.5163

>T146108 WP_000854821.1 NZ_CP047378:4732917-4733294 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T146108 NZ_CP062723:2648220-2648375 [Escherichia coli O157:H7]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTGCGAATCCGAACCGGTCAGACGGAGGTCGCTGTCTTCGTAGACTACGAATCTGAGAAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13606.39 Da        Isoelectric Point: 6.0618

>AT146108 WP_001285610.1 NZ_CP047378:4732459-4732827 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT146108 NZ_CP062723:c2648208-2648150 [Escherichia coli O157:H7]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W4PV54

Antitoxin

Source ID Structure

References