Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3487888..3488665 | Replicon | chromosome |
| Accession | NZ_CP047378 | ||
| Organism | Escherichia coli strain CAU16175 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | S1P968 |
| Locus tag | GTP13_RS17935 | Protein ID | WP_000854814.1 |
| Coordinates | 3488291..3488665 (+) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | GTP13_RS17930 | Protein ID | WP_167582999.1 |
| Coordinates | 3487888..3488202 (+) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GTP13_RS17895 | 3483066..3484136 | + | 1071 | WP_000102669.1 | patatin-like phospholipase family protein | - |
| GTP13_RS17900 | 3484468..3484956 | + | 489 | WP_000825476.1 | hypothetical protein | - |
| GTP13_RS17905 | 3484972..3485382 | + | 411 | WP_000846713.1 | hypothetical protein | - |
| GTP13_RS17910 | 3485603..3486424 | + | 822 | WP_001234530.1 | DUF945 domain-containing protein | - |
| GTP13_RS17915 | 3486506..3486985 | + | 480 | WP_000860076.1 | antirestriction protein | - |
| GTP13_RS17920 | 3487001..3487477 | + | 477 | WP_001186773.1 | RadC family protein | - |
| GTP13_RS17925 | 3487540..3487761 | + | 222 | WP_000692323.1 | DUF987 domain-containing protein | - |
| GTP13_RS17930 | 3487888..3488202 | + | 315 | WP_167582999.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| GTP13_RS17935 | 3488291..3488665 | + | 375 | WP_000854814.1 | type IV toxin-antitoxin system toxin CbtA | Toxin |
| GTP13_RS17940 | 3488662..3488856 | + | 195 | WP_000988600.1 | hypothetical protein | - |
| GTP13_RS17945 | 3488869..3488982 | + | 114 | WP_001161660.1 | DUF957 domain-containing protein | - |
| GTP13_RS17950 | 3489271..3489399 | - | 129 | Protein_3493 | transposase domain-containing protein | - |
| GTP13_RS17955 | 3489471..3489653 | + | 183 | WP_104772123.1 | ethanolamine utilization protein | - |
| GTP13_RS17960 | 3489754..3490083 | - | 330 | WP_000450409.1 | DUF496 family protein | - |
| GTP13_RS17965 | 3490255..3491313 | - | 1059 | WP_001200891.1 | FUSC family protein | - |
| GTP13_RS17970 | 3491512..3491985 | - | 474 | WP_001105414.1 | DNA gyrase inhibitor SbmC | - |
| GTP13_RS17975 | 3492104..3493270 | - | 1167 | WP_167582801.1 | serine-type D-Ala-D-Ala carboxypeptidase DacD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 13898.94 Da Isoelectric Point: 7.8522
>T146102 WP_000854814.1 NZ_CP047378:3488291-3488665 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
Download Length: 375 bp
>T146102 NZ_CP062723:c457202-456717 [Escherichia coli O157:H7]
ATGGGAATAACGGCTCCTACTCCCCTAACGTCTGAACATAATCTGGCTGACTTTTGCTGTTCCGATCACGGGATGAATGA
ATGGCTAAAAAAGAAAGCGTTAAAAAATCACAGCTCCGGTCTGTCTCGTGTTTACGTTATCTGTATTGCCAATACCCGCC
AGGTAATCGGCTATTACTGCCTTTCTACAGGCAGTATTCAACGTAATTTGGCCCCTGGAGCCATGCGACGTAATGCTCCC
GAATCGTTGCCTGTTGTCGTATTAGGCAGACTGGCAATTGATCAAGCCTGGGCAGGTAAAGGGTTGGGCGTCGCATTGTT
GAAAGATGCAGTCTATCGCACAATGTCCATAGCTCAACAGGTAGGGGTTCGTGCGCTCATTGTTCATGCCTTAGACGATT
CAGTACGCAATTTCTATCTGAAGTATGCCTTTGTACCTTCACCATTCCAGTCACTTACCTTACTGTATCCCATTACTCTG
GAGTAA
ATGGGAATAACGGCTCCTACTCCCCTAACGTCTGAACATAATCTGGCTGACTTTTGCTGTTCCGATCACGGGATGAATGA
ATGGCTAAAAAAGAAAGCGTTAAAAAATCACAGCTCCGGTCTGTCTCGTGTTTACGTTATCTGTATTGCCAATACCCGCC
AGGTAATCGGCTATTACTGCCTTTCTACAGGCAGTATTCAACGTAATTTGGCCCCTGGAGCCATGCGACGTAATGCTCCC
GAATCGTTGCCTGTTGTCGTATTAGGCAGACTGGCAATTGATCAAGCCTGGGCAGGTAAAGGGTTGGGCGTCGCATTGTT
GAAAGATGCAGTCTATCGCACAATGTCCATAGCTCAACAGGTAGGGGTTCGTGCGCTCATTGTTCATGCCTTAGACGATT
CAGTACGCAATTTCTATCTGAAGTATGCCTTTGTACCTTCACCATTCCAGTCACTTACCTTACTGTATCCCATTACTCTG
GAGTAA
Antitoxin
Download Length: 105 a.a. Molecular weight: 11519.35 Da Isoelectric Point: 7.2621
>AT146102 WP_167582999.1 NZ_CP047378:3487888-3488202 [Escherichia coli]
MVGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSGELNPRHQHTVTLYAKGLT
CKADTLSSCGYVYLAVYPTPEMKN
MVGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSGELNPRHQHTVTLYAKGLT
CKADTLSSCGYVYLAVYPTPEMKN
Download Length: 315 bp
>AT146102 NZ_CP062723:c457471-457193 [Escherichia coli O157:H7]
ATGAAACCGGAAAGCAAAGAAGCGCCAATCAATATCAGAGCGAAAGCCTCACAGCGTGACCTGATTGATATGGCAGCGAA
TCTGGTCGCAAAATCGCGCACTGATTTTATGCTGGATGCCGCATGCCGTGAAGCGCAAGACATCTTATTAGATCAACGAC
TATTCATCCTTGATGACGAGCAATACGATGCGTTTCTCGCTGCCCTGGACGCCCCCATCACTGCTGAGCGTCAGGCCAAA
ATTAACGCGTTGATGAATCGTAAATCGCCATGGGAATAA
ATGAAACCGGAAAGCAAAGAAGCGCCAATCAATATCAGAGCGAAAGCCTCACAGCGTGACCTGATTGATATGGCAGCGAA
TCTGGTCGCAAAATCGCGCACTGATTTTATGCTGGATGCCGCATGCCGTGAAGCGCAAGACATCTTATTAGATCAACGAC
TATTCATCCTTGATGACGAGCAATACGATGCGTTTCTCGCTGCCCTGGACGCCCCCATCACTGCTGAGCGTCAGGCCAAA
ATTAACGCGTTGATGAATCGTAAATCGCCATGGGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|