Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2195599..2196394 Replicon chromosome
Accession NZ_CP047378
Organism Escherichia coli strain CAU16175

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag GTP13_RS10910 Protein ID WP_000854914.1
Coordinates 2196020..2196394 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag GTP13_RS10905 Protein ID WP_001280954.1
Coordinates 2195599..2195973 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTP13_RS10875 2190954..2191859 + 906 WP_167582665.1 chemotaxis protein -
GTP13_RS10880 2191856..2192926 + 1071 WP_000102669.1 patatin-like phospholipase family protein -
GTP13_RS10885 2193266..2194084 + 819 WP_024219686.1 DUF945 domain-containing protein -
GTP13_RS10890 2194175..2194660 + 486 WP_000214398.1 antirestriction protein -
GTP13_RS10895 2194676..2195152 + 477 WP_001186738.1 RadC family protein -
GTP13_RS10900 2195215..2195436 + 222 WP_001220314.1 DUF987 domain-containing protein -
GTP13_RS10905 2195599..2195973 + 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
GTP13_RS10910 2196020..2196394 + 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
GTP13_RS10915 2196391..2196882 + 492 WP_000976857.1 hypothetical protein -
GTP13_RS10920 2196894..2197091 + 198 WP_000839282.1 DUF957 domain-containing protein -
GTP13_RS10925 2197176..2198018 + 843 WP_096317471.1 DUF4942 domain-containing protein -
GTP13_RS10935 2198489..2199427 + 939 WP_096245843.1 glyoxylate/hydroxypyruvate reductase GhrA -
GTP13_RS10940 2199482..2200219 + 738 WP_000283664.1 zinc-binding phosphatase -
GTP13_RS10945 2200243..2200797 + 555 WP_001001902.1 molecular chaperone YcdY -
GTP13_RS10950 2200899..2201390 + 492 WP_001297187.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T146080 WP_000854914.1 NZ_CP047378:2196020-2196394 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T146080 NZ_CP047378:2196020-2196394 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCTTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT146080 WP_001280954.1 NZ_CP047378:2195599-2195973 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT146080 NZ_CP047378:2195599-2195973 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCATGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References