Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 709903..710735 Replicon chromosome
Accession NZ_CP047378
Organism Escherichia coli strain CAU16175

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag GTP13_RS03515 Protein ID WP_000854753.1
Coordinates 710361..710735 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID V0ULY5
Locus tag GTP13_RS03510 Protein ID WP_001315620.1
Coordinates 709903..710271 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTP13_RS03475 705219..706757 + 1539 WP_000099160.1 IS66-like element ISEc22 family transposase -
GTP13_RS03480 706754..707194 + 441 WP_096317830.1 hypothetical protein -
GTP13_RS03485 707273..707506 + 234 WP_001119729.1 DUF905 family protein -
GTP13_RS03490 707606..708424 + 819 WP_001234620.1 DUF945 domain-containing protein -
GTP13_RS03495 708479..708964 + 486 WP_000849588.1 antirestriction protein -
GTP13_RS03500 708980..709456 + 477 WP_001186774.1 RadC family protein -
GTP13_RS03505 709519..709740 + 222 WP_000692345.1 DUF987 domain-containing protein -
GTP13_RS03510 709903..710271 + 369 WP_001315620.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
GTP13_RS03515 710361..710735 + 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
GTP13_RS03520 710732..711220 + 489 WP_000777547.1 hypothetical protein -
GTP13_RS03525 711232..711432 + 201 WP_096317592.1 DUF957 domain-containing protein -
GTP13_RS03530 711517..711669 + 153 WP_001280445.1 hypothetical protein -
GTP13_RS03545 712722..713371 + 650 Protein_684 HNH endonuclease -
GTP13_RS03550 713379..714359 - 981 WP_000991415.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
GTP13_RS03555 714424..715530 - 1107 WP_167582592.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - fimB / fimE 682626..719398 36772


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T146074 WP_000854753.1 NZ_CP047378:710361-710735 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T146074 NZ_CP062721:c708868-708404 [Escherichia coli O157:H7]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13474.20 Da        Isoelectric Point: 6.2050

>AT146074 WP_001315620.1 NZ_CP047378:709903-710271 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT146074 NZ_CP062721:c709203-708868 [Escherichia coli O157:H7]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAGCAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATACAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0

Antitoxin

Source ID Structure
AlphaFold DB V0ULY5

References