Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | chpSB/PRK09812-ChpS |
| Location | 642623..643218 | Replicon | chromosome |
| Accession | NZ_CP047378 | ||
| Organism | Escherichia coli strain CAU16175 | ||
Toxin (Protein)
| Gene name | chpB | Uniprot ID | U9Y4M4 |
| Locus tag | GTP13_RS03180 | Protein ID | WP_000239579.1 |
| Coordinates | 642868..643218 (+) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | chpS | Uniprot ID | - |
| Locus tag | GTP13_RS03175 | Protein ID | WP_096317499.1 |
| Coordinates | 642623..642874 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GTP13_RS03120 | 638353..638556 | - | 204 | WP_001036809.1 | hypothetical protein | - |
| GTP13_RS03125 | 638553..638867 | - | 315 | WP_046788693.1 | ead/Ea22-like family protein | - |
| GTP13_RS03130 | 638864..639109 | - | 246 | WP_000153676.1 | winged helix-turn-helix domain-containing protein | - |
| GTP13_RS03135 | 639106..639309 | - | 204 | WP_001560998.1 | hypothetical protein | - |
| GTP13_RS03140 | 639396..639509 | - | 114 | WP_000021656.1 | hypothetical protein | - |
| GTP13_RS03145 | 639506..639748 | - | 243 | WP_000514277.1 | DUF4754 family protein | - |
| GTP13_RS03150 | 639760..640038 | - | 279 | WP_000159895.1 | hypothetical protein | - |
| GTP13_RS03155 | 640049..640399 | - | 351 | WP_167582583.1 | DUF4761 family protein | - |
| GTP13_RS03160 | 640437..640862 | - | 426 | WP_001158283.1 | regulatory protein | - |
| GTP13_RS03165 | 640971..641270 | + | 300 | WP_021580386.1 | helix-turn-helix transcriptional regulator | - |
| GTP13_RS03170 | 641337..642332 | + | 996 | WP_001372721.1 | tyrosine-type recombinase/integrase | - |
| GTP13_RS03175 | 642623..642874 | + | 252 | WP_096317499.1 | type II toxin-antitoxin system antitoxin ChpS | Antitoxin |
| GTP13_RS03180 | 642868..643218 | + | 351 | WP_000239579.1 | endoribonuclease toxin ChpB | Toxin |
| GTP13_RS03185 | 643298..643828 | - | 531 | WP_000055075.1 | inorganic diphosphatase | - |
| GTP13_RS03190 | 644138..645094 | + | 957 | WP_000265933.1 | galactofuranose ABC transporter substrate-binding protein YtfQ | - |
| GTP13_RS03195 | 645234..646736 | + | 1503 | WP_167582586.1 | sugar ABC transporter ATP-binding protein | - |
| GTP13_RS03200 | 646750..647772 | + | 1023 | WP_001296689.1 | ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 608436..656862 | 48426 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12511.45 Da Isoelectric Point: 5.6219
>T146073 WP_000239579.1 NZ_CP047378:642868-643218 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE
Download Length: 351 bp
>T146073 NZ_CP062721:c457207-456722 [Escherichia coli O157:H7]
ATGGGAATAACGGCTCCTACTCCCCTAACGTCTGAACATAATCTGGCTGACTTTTGCTGTTCCGATCACGGGATGAATGA
ATGGCTAAAAAAGAAAGCGTTAAAAAATCACAGCTCCGGTCTGTCTCGTGTTTACGTTATCTGTATTGCCAATACCCGCC
AGGTAATCGGCTATTACTGCCTTTCTACAGGCAGTATTCAACGTAATTTGGCCCCTGGAGCCATGCGACGTAATGCTCCC
GAATCGTTGCCTGTTGTCGTATTAGGCAGACTGGCAATTGATCAAGCCTGGGCAGGTAAAGGGTTGGGCGTCGCATTGTT
GAAAGATGCAGTCTATCGCACAATGTCCATAGCTCAACAGGTAGGGGTTCGTGCGCTCATTGTTCATGCCTTAGACGATT
CAGTACGCAATTTCTATCTGAAGTATGCCTTTGTACCTTCACCATTCCAGTCACTTACCTTACTGTATCCCATTACTCTG
GAGTAA
ATGGGAATAACGGCTCCTACTCCCCTAACGTCTGAACATAATCTGGCTGACTTTTGCTGTTCCGATCACGGGATGAATGA
ATGGCTAAAAAAGAAAGCGTTAAAAAATCACAGCTCCGGTCTGTCTCGTGTTTACGTTATCTGTATTGCCAATACCCGCC
AGGTAATCGGCTATTACTGCCTTTCTACAGGCAGTATTCAACGTAATTTGGCCCCTGGAGCCATGCGACGTAATGCTCCC
GAATCGTTGCCTGTTGTCGTATTAGGCAGACTGGCAATTGATCAAGCCTGGGCAGGTAAAGGGTTGGGCGTCGCATTGTT
GAAAGATGCAGTCTATCGCACAATGTCCATAGCTCAACAGGTAGGGGTTCGTGCGCTCATTGTTCATGCCTTAGACGATT
CAGTACGCAATTTCTATCTGAAGTATGCCTTTGTACCTTCACCATTCCAGTCACTTACCTTACTGTATCCCATTACTCTG
GAGTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9303.64 Da Isoelectric Point: 4.4201
>AT146073 WP_096317499.1 NZ_CP047378:642623-642874 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQMSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQMSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW
Download Length: 252 bp
>AT146073 NZ_CP062721:c457476-457198 [Escherichia coli O157:H7]
ATGAAACCGGAAAGCAAAGAAGCGCCAATCAATATCAGAGCGAAAGCCTCACAGCGTGACCTGATTGATATGGCAGCGAA
TCTGGTCGCAAAATCGCGCACTGATTTTATGCTGGATGCCGCATGCCGTGAAGCGCAAGACATCTTATTAGATCAACGAC
TATTCATCCTTGATGACGAGCAATACGATGCGTTTCTCGCTGCCCTGGACGCCCCCATCACTGCTGAGCGTCAGGCCAAA
ATTAACGCGTTGATGAATCGTAAATCGCCATGGGAATAA
ATGAAACCGGAAAGCAAAGAAGCGCCAATCAATATCAGAGCGAAAGCCTCACAGCGTGACCTGATTGATATGGCAGCGAA
TCTGGTCGCAAAATCGCGCACTGATTTTATGCTGGATGCCGCATGCCGTGAAGCGCAAGACATCTTATTAGATCAACGAC
TATTCATCCTTGATGACGAGCAATACGATGCGTTTCTCGCTGCCCTGGACGCCCCCATCACTGCTGAGCGTCAGGCCAAA
ATTAACGCGTTGATGAATCGTAAATCGCCATGGGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|