Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-RHH |
| Location | 48291..48847 | Replicon | plasmid p1AsJ410 |
| Accession | NZ_CP047377 | ||
| Organism | Aeromonas salmonicida subsp. salmonicida strain J410 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | GO994_RS22600 | Protein ID | WP_159365015.1 |
| Coordinates | 48291..48566 (-) | Length | 92 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | GO994_RS22605 | Protein ID | WP_174416604.1 |
| Coordinates | 48566..48847 (-) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GO994_RS22560 | 43609..43971 | - | 363 | WP_139394881.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
| GO994_RS22565 | 43971..44231 | - | 261 | WP_139394880.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| GO994_RS22570 | 44332..44717 | - | 386 | Protein_65 | hypothetical protein | - |
| GO994_RS22575 | 44913..45008 | + | 96 | Protein_66 | IS5/IS1182 family transposase | - |
| GO994_RS22580 | 45005..45967 | - | 963 | Protein_67 | IS630 family transposase | - |
| GO994_RS22585 | 46056..46385 | - | 330 | WP_159365013.1 | YcaO-like family protein | - |
| GO994_RS22590 | 46382..46588 | - | 207 | WP_159365014.1 | hypothetical protein | - |
| GO994_RS22595 | 46590..47504 | - | 915 | WP_042468951.1 | TOMM precursor leader peptide-binding protein | - |
| GO994_RS22600 | 48291..48566 | - | 276 | WP_159365015.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| GO994_RS22605 | 48566..48847 | - | 282 | WP_174416604.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
| GO994_RS22610 | 49059..49619 | + | 561 | WP_042468955.1 | recombinase family protein | - |
| GO994_RS22615 | 49623..52651 | + | 3029 | Protein_74 | Tn3 family transposase | - |
| GO994_RS22620 | 52686..53360 | + | 675 | Protein_75 | IS21 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | ascL / ascK / ascJ / ascI / ascH / ascG / ascF / ascE / ascD / ascC / ascB / exsD / exsA / exsB / exsE / exsC / aopD / aopB / acrH / acrV / acrG / acrR / ascV / ascY / ascX / acr2 / acr1 / aopN / ascN / ascO / ascP / ascQ / ascR / ascS / ascT / ascT / ascU / sycO / aopO / ati2 / ati1 | 1..72285 | 72285 | |
| - | inside | IScluster/Tn | - | sycO / aopO / ati2 / ati1 | 29944..72097 | 42153 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10642.40 Da Isoelectric Point: 8.4730
>T146070 WP_159365015.1 NZ_CP047377:c48566-48291 [Aeromonas salmonicida subsp. salmonicida]
MELKWTSKALSDLARLYEFLALANKPAAARAVQALTQAPTILLTNPRIGEQLFQFEPREVRRILVGEYEVRYEILDSIIY
VLLLWHTRENR
MELKWTSKALSDLARLYEFLALANKPAAARAVQALTQAPTILLTNPRIGEQLFQFEPREVRRILVGEYEVRYEILDSIIY
VLLLWHTRENR
Download Length: 276 bp
>T146070 NZ_CP062721:365363-365638 [Escherichia coli O157:H7]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGC
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGC
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA
Antitoxin
Download Length: 94 a.a. Molecular weight: 10351.80 Da Isoelectric Point: 5.6624
>AT146070 WP_174416604.1 NZ_CP047377:c48847-48566 [Aeromonas salmonicida subsp. salmonicida]
MKGNMTQATTKVLTAHVPLPMADKVDQMAARLERSRGWIMKQALSAWLAQEEDRDRLTQEALADVDAGRVIDHLAVQAWA
DSLNTDQPLSVPR
MKGNMTQATTKVLTAHVPLPMADKVDQMAARLERSRGWIMKQALSAWLAQEEDRDRLTQEALADVDAGRVIDHLAVQAWA
DSLNTDQPLSVPR
Download Length: 282 bp
>AT146070 NZ_CP062721:365635-365994 [Escherichia coli O157:H7]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|