Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/PRK09907-MazE
Location 1449466..1449884 Replicon chromosome
Accession NZ_CP047363
Organism Macrococcus canis strain Epi0076A

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag GTN30_RS07670 Protein ID WP_164953571.1
Coordinates 1449466..1449648 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag GTN30_RS07675 Protein ID WP_133418962.1
Coordinates 1449642..1449884 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTN30_RS07650 1445126..1446529 - 1404 WP_164942239.1 NADP-dependent phosphogluconate dehydrogenase -
GTN30_RS07655 1446589..1447695 - 1107 WP_164953569.1 M20/M25/M40 family metallo-hydrolase -
GTN30_RS07660 1447946..1448914 - 969 WP_164953570.1 aromatic acid exporter family protein -
GTN30_RS07665 1448918..1449355 - 438 WP_086042626.1 BrxA/BrxB family bacilliredoxin -
GTN30_RS07670 1449466..1449648 - 183 WP_164953571.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
GTN30_RS07675 1449642..1449884 - 243 WP_133418962.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
GTN30_RS07685 1451015..1451332 - 318 WP_164953573.1 hypothetical protein -
GTN30_RS07690 1451519..1452619 - 1101 WP_164953574.1 Glu/Leu/Phe/Val dehydrogenase -
GTN30_RS07695 1452792..1453025 + 234 WP_086042628.1 DUF2627 domain-containing protein -
GTN30_RS07700 1453056..1453781 - 726 WP_158290711.1 glycerophosphodiester phosphodiesterase -
GTN30_RS07705 1453784..1454455 - 672 WP_138071425.1 response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-54)

Antitoxin

SpoVT-AbrB domain

(6-48)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6578.52 Da        Isoelectric Point: 6.9727

>T146063 WP_164953571.1 NZ_CP047363:c1449648-1449466 [Macrococcus canis]
MVEQGTIIKLDLNPTKGKEQAGYRPALVISNKDFNEFTNLAILCPISSTSNSFPSAKHEL

Download         Length: 183 bp

>T146063 NZ_CP062719:4867030-4867371 [Escherichia coli O157:H7]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9539.83 Da        Isoelectric Point: 8.5782

>AT146063 WP_133418962.1 NZ_CP047363:c1449884-1449642 [Macrococcus canis]
MQVSLQRWGNSQGIRIPKSIVNEMNLDKNQKFDLTMQDEKIILTKQQQNVSLIRELFENYKTENKPSEFDWGKPRGNEVW

Download         Length: 243 bp

>AT146063 NZ_CP062719:c4867035-4866959 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References