146062

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1320176..1320663 Replicon chromosome
Accession NZ_CP047363
Organism Macrococcus canis strain Epi0076A

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag GTN30_RS06955 Protein ID WP_138071166.1
Coordinates 1320397..1320663 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag GTN30_RS06950 Protein ID WP_138071164.1
Coordinates 1320176..1320400 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTN30_RS06915 1315735..1316181 - 447 WP_158290696.1 GNAT family N-acetyltransferase -
GTN30_RS06920 1316263..1317003 + 741 WP_164953486.1 hypothetical protein -
GTN30_RS06925 1317013..1317903 + 891 WP_164953487.1 phosphotransferase -
GTN30_RS06930 1318089..1318574 + 486 WP_164953488.1 NUDIX domain-containing protein -
GTN30_RS06935 1318580..1319347 + 768 WP_164953489.1 hypothetical protein -
GTN30_RS06940 1319365..1319637 - 273 WP_164953490.1 Txe/YoeB family addiction module toxin -
GTN30_RS06945 1319630..1319887 - 258 WP_164953491.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
GTN30_RS06950 1320176..1320400 + 225 WP_138071164.1 toxin-antitoxin system, antitoxin component Antitoxin
GTN30_RS06955 1320397..1320663 + 267 WP_138071166.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GTN30_RS06960 1320766..1321260 + 495 WP_164953492.1 hypothetical protein -
GTN30_RS06965 1321421..1322638 + 1218 WP_164953493.1 ATP-binding protein -
GTN30_RS06970 1322774..1324036 + 1263 WP_164953494.1 Y-family DNA polymerase -
GTN30_RS06975 1324180..1324368 + 189 WP_164953495.1 hypothetical protein -
GTN30_RS06980 1324527..1324826 + 300 WP_096076536.1 DUF4298 domain-containing protein -
GTN30_RS06985 1324890..1325366 - 477 WP_202983269.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10539.32 Da        Isoelectric Point: 10.4082

>T146062 WP_138071166.1 NZ_CP047363:1320397-1320663 [Macrococcus canis]
MKYSIEYDPKVIKQLRKMDPQSSRLLLQWINKNIVHCEDPRSSGKALTGNYSGFWRYRVGQFRIITKIEDDKLIILVISI
DHRKNIYR

Download         Length: 267 bp

>T146062 NZ_CP062719:c4751177-4750863 [Escherichia coli O157:H7]
ATGCAATTTACGGTATACCGCAGTCGCAGTAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGTGATTAATCGCCGTATTGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8745.95 Da        Isoelectric Point: 4.5816

>AT146062 WP_138071164.1 NZ_CP047363:1320176-1320400 [Macrococcus canis]
MATITIRVSEDEKNFLKYMSEFMNLSLTDLIKNYTIEDLEDLFDTHVADKAYIEWSKHKQTVSHNDVMKEFGLL

Download         Length: 225 bp

>AT146062 NZ_CP062719:c4751413-4751180 [Escherichia coli O157:H7]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CTGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References