Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/Txe-RelB
Location 534015..534522 Replicon chromosome
Accession NZ_CP047359
Organism Rickettsia japonica strain LA16/2015

Toxin (Protein)


Gene name relB Uniprot ID G4KM08
Locus tag GRX81_RS03200 Protein ID WP_014013837.1
Coordinates 534015..534278 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID G4KM09
Locus tag GRX81_RS03205 Protein ID WP_014013838.1
Coordinates 534271..534522 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GRX81_RS03165 529109..529228 + 120 WP_158309284.1 palindromic element RPE4 domain-containing protein -
GRX81_RS03170 529516..529902 + 387 Protein_605 hypothetical protein -
GRX81_RS03175 529981..530250 + 270 WP_096368100.1 hypothetical protein -
GRX81_RS03180 530272..530448 + 177 WP_158309285.1 hypothetical protein -
GRX81_RS03185 530552..531946 - 1395 WP_014120498.1 lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase -
GRX81_RS03190 531943..532599 - 657 WP_014013835.1 lysophospholipid acyltransferase family protein -
GRX81_RS03195 532750..533955 - 1206 WP_014120499.1 pyridoxal phosphate-dependent aminotransferase -
GRX81_RS03200 534015..534278 - 264 WP_014013837.1 Txe/YoeB family addiction module toxin Toxin
GRX81_RS03205 534271..534522 - 252 WP_014013838.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GRX81_RS03210 534662..535666 + 1005 WP_014120500.1 methyltransferase domain-containing protein -
GRX81_RS03215 535671..536426 + 756 WP_024704441.1 VacJ family lipoprotein -
GRX81_RS03220 536446..537045 + 600 WP_014120502.1 phospholipid-binding protein MlaC -
GRX81_RS03225 537270..537557 + 288 WP_024704442.1 ribose-phosphate pyrophosphokinase-like domain-containing protein -
GRX81_RS07710 537666..538133 + 468 WP_186786268.1 palindromic element RPE1 domain-containing protein -
GRX81_RS03240 538278..539345 + 1068 WP_014120503.1 alanine racemase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10590.39 Da        Isoelectric Point: 9.8255

>T146040 WP_014013837.1 NZ_CP047359:c534278-534015 [Rickettsia japonica]
MIEIEWTLEAAEDLVYWKKYDIKKYERIKLLIKNIQEASFTGIGKPEPLKHILSGLWSRRINHEHRLIYSVNTKQIIIYN
CRFHYKN

Download         Length: 264 bp

>T146040 NZ_CP062719:283376-283483 [Escherichia coli O157:H7]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9537.81 Da        Isoelectric Point: 9.4884

>AT146040 WP_014013838.1 NZ_CP047359:c534522-534271 [Rickettsia japonica]
MNSISGTSFRKNLSSVLNTVENDHVPYLIKRKNHKNIILLTEEEYESTKETLYLLSNLANANRIKKSIEQAKRGEFAKVN
LDD

Download         Length: 252 bp

>AT146040 NZ_CP062719:c283328-283262 [Escherichia coli O157:H7]
GGTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F3RG12

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3RZ38

References