Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-MqsA
Location 3668224..3668923 Replicon chromosome
Accession NZ_CP047349
Organism Proteus terrae subsp. cibarius strain ZN2

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag GTH25_RS16805 Protein ID WP_075671320.1
Coordinates 3668224..3668610 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag GTH25_RS16810 Protein ID WP_075671318.1
Coordinates 3668603..3668923 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTH25_RS16790 3664262..3664846 - 585 WP_109419307.1 DNA-3-methyladenine glycosylase I -
GTH25_RS16795 3665085..3665990 + 906 WP_004246832.1 glycine--tRNA ligase subunit alpha -
GTH25_RS16800 3666000..3668072 + 2073 WP_075671322.1 glycine--tRNA ligase subunit beta -
GTH25_RS16805 3668224..3668610 + 387 WP_075671320.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GTH25_RS16810 3668603..3668923 + 321 WP_075671318.1 helix-turn-helix domain-containing protein Antitoxin
GTH25_RS16815 3668991..3669311 - 321 WP_075671316.1 hypothetical protein -
GTH25_RS16820 3669417..3670703 - 1287 WP_075671314.1 DUF3748 domain-containing protein -
GTH25_RS16825 3670840..3671457 + 618 WP_006534609.1 trimeric intracellular cation channel family protein -
GTH25_RS16830 3671763..3672386 + 624 WP_006534608.1 guanylate kinase -
GTH25_RS16835 3672441..3672716 + 276 WP_004246820.1 DNA-directed RNA polymerase subunit omega -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-125)

Antitoxin

Cro/C1-type helix-turn-helix domain

(50-96)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14358.75 Da        Isoelectric Point: 10.0463

>T146031 WP_075671320.1 NZ_CP047349:3668224-3668610 [Proteus terrae subsp. cibarius]
MVIYKTKMFKNSFKKMPINDAALIDIANEVYAGHFEADLGGGIIKKRICIHGKGKSSGIRTIIFYKQGSNLFFADGWKKS
HLSAKKSKEITDDELESYKDLAKDLFSATKNKIDKMVALGLLTEVKHD

Download         Length: 387 bp

>T146031 NZ_CP062717:c4500061-4499663 [Escherichia coli O157:H7]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAGCTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACTTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAATCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12068.99 Da        Isoelectric Point: 10.0482

>AT146031 WP_075671318.1 NZ_CP047349:3668603-3668923 [Proteus terrae subsp. cibarius]
MTDKMQEMLKFAQEMEVAGITDGESARRIAARIKAKELKERYAHLTPMNGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLNLIDNKAISI

Download         Length: 321 bp

>AT146031 NZ_CP062717:c4500357-4500064 [Escherichia coli O157:H7]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAATTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References