Detailed information of TA system TA146029

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 3363741..3365488
• Replicon: chromosome
• Accession: NZ_CP047349
• Organism: Proteus terrae subsp. cibarius strain ZN2

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: GTH25_RS15455
• Protein ID: WP_098941872.1
• Coordinates: 3363741..3365114 (+)
• Length: 458 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: GTH25_RS15460
• Protein ID: WP_098941871.1
• Coordinates: 3365111..3365488 (+)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GTH25_RS15440	3359412..3360395	-	984	WP_075673449.1	ABC transporter permease	-
GTH25_RS15445	3360380..3361963	-	1584	WP_164530721.1	ABC transporter substrate-binding protein	-
GTH25_RS15450	3362369..3363358	-	990	WP_156734136.1	glycosyltransferase	-
GTH25_RS15455	3363741..3365114	+	1374	WP_098941872.1	type II toxin-antitoxin system HipA family toxin	Toxin
GTH25_RS15460	3365111..3365488	+	378	WP_098941871.1	helix-turn-helix domain-containing protein	Antitoxin
GTH25_RS15465	3365610..3366110	-	501	WP_164530722.1	hydrogenase maturation peptidase HycI	-
GTH25_RS15470	3366107..3366517	-	411	WP_088494545.1	formate hydrogenlyase maturation HycH family protein	-
GTH25_RS15475	3366510..3367292	-	783	WP_072069032.1	NADH-quinone oxidoreductase subunit B family protein	-
GTH25_RS15480	3367289..3367843	-	555	WP_075673442.1	hydrogenase 4 subunit H	-
GTH25_RS15485	3367855..3369588	-	1734	WP_075673441.1	hydrogenase large subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (174-418)

Antitoxin

• Cro/C1-type helix-turn-helix domain (48-103)

Sequences

Toxin

Protein

• Length: 458 a.a.
• Molecular weight: 52589.44 Da
• Isoelectric Point: 4.6415

>T146029 WP_098941872.1 NZ_CP047349:3363741-3365114 [Proteus terrae subsp. cibarius]
MEKITLQAFLNQEWVDIAIINFPKYDRMLYASKYDITYPITELEYETSYSIEHLYQDDQHAVSINHPVELYFDDSGSPGW
LKFLDDIVPSGASRRYWLQYLDIAELSTEQQNYELLHHGTISPIGNLRVKESLPAPSPLNRNLFFTINDVKNRASDFLDY
AQRKGAAAGGATGAGGEAPKLLLRCNDNEEVWIDTYQDDISNLDKYYLVKFPRGSRSVVDCNILRTEYHFYHELTDMGFD
TIPIKDMRLEEGDNYPSLWLPRFDIKIENNKIIRLAMESVYSILNKAPGTTLYHETVIKELIDKINQSNMVTEFGFQFNT
ANFIIEWVRRDLLNIIFGNSDNHGRNTSLIRYNNAIYLAPIYDFAPMKADPEGIARTTKWGSHSEIGGEYNFINIADSLS
DLIAPEQLLNALQETAQQLLTLKERLEMRGVPTQILTMPSFGFDFIPNKLERWGLLP

Nucleotide

• Length: 1374 bp

>T146029 NZ_CP062717:3786132-3786518 [Escherichia coli O157:H7]
ATGGGTGTGTATAAGGCAAGGCGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAAGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGGTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAAGCAAAGAAATCGAAGATGATGAACTGGCAGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTCTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 14108.43 Da
• Isoelectric Point: 10.5220

>AT146029 WP_098941871.1 NZ_CP047349:3365111-3365488 [Proteus terrae subsp. cibarius]
MNNVENKNHIDKFPTRASRKHQFVATTDRKQVISKIMAHLLFGEITQGEALKMLRIKVLGLNQDLYAKLINVSRKTLSEI
ENDRGNYSADIINKVFKPFGLKVGLVPSSPHILSSLLKESPPINE

Nucleotide

• Length: 378 bp

>AT146029 NZ_CP062717:3786508-3786837 [Escherichia coli O157:H7]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAGGTTGA
TGCCATTGCCGTCATGGTCAAAGCCCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCACTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA