Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 3287749..3289471 Replicon chromosome
Accession NZ_CP047349
Organism Proteus terrae subsp. cibarius strain ZN2

Toxin (Protein)


Gene name mosT Uniprot ID A0A6G6SX12
Locus tag GTH25_RS15110 Protein ID WP_054103802.1
Coordinates 3287749..3288687 (-) Length 313 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A0A0M0HVB9
Locus tag GTH25_RS15115 Protein ID WP_002026815.1
Coordinates 3288680..3289471 (-) Length 264 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTH25_RS15100 3283903..3284724 - 822 WP_087529689.1 TnsA endonuclease N-terminal domain-containing protein -
GTH25_RS15105 3284859..3287168 - 2310 Protein_2915 AAA family ATPase -
GTH25_RS15110 3287749..3288687 - 939 WP_054103802.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
GTH25_RS15115 3288680..3289471 - 792 WP_002026815.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
GTH25_RS15120 3289692..3290078 - 387 WP_164530709.1 hypothetical protein -
GTH25_RS15125 3290075..3290647 - 573 WP_164530710.1 type IV conjugative transfer system lipoprotein TraV -
GTH25_RS15130 3290722..3292011 - 1290 WP_164530711.1 TraB/VirB10 family protein -
GTH25_RS15135 3292014..3292910 - 897 WP_164530816.1 type-F conjugative transfer system secretin TraK -
GTH25_RS15140 3292894..3293520 - 627 WP_025441422.1 pilus assembly protein -
GTH25_RS15145 3293517..3293798 - 282 WP_000433891.1 type IV conjugative transfer system protein TraL -
GTH25_RS15150 3293979..3294302 + 324 WP_164530712.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element tet(H) / dfrA1 - 3170091..3311563 141472


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-97)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 35629.99 Da        Isoelectric Point: 5.0082

>T146027 WP_054103802.1 NZ_CP047349:c3288687-3287749 [Proteus terrae subsp. cibarius]
MDKDSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALINVRAALQRITDRINIQ
PDIRAAFQDNKADELRIVVSSPVATIKIEVSPVARGTLHRAEIMPVQESVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGISREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLIELQK
HFTERDHAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE

Download         Length: 939 bp

>T146027 NZ_CP062717:c3613223-3613068 [Escherichia coli O157:H7]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAGTCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 264 a.a.        Molecular weight: 30116.50 Da        Isoelectric Point: 9.1901

>AT146027 WP_002026815.1 NZ_CP047349:c3289471-3288680 [Proteus terrae subsp. cibarius]
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLCSGVYYRPDAQGDIKPTWVDAIQALDVQLGVSVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRIDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG

Download         Length: 792 bp

>AT146027 NZ_CP062717:3613235-3613293 [Escherichia coli O157:H7]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6G6SX12

Antitoxin

Source ID Structure
AlphaFold DB A0A0M0HVB9

References