Detailed information of TA system TA146026

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/GNAT-DUF1778
• Location: 2331387..2332132
• Replicon: chromosome
• Accession: NZ_CP047349
• Organism: Proteus terrae subsp. cibarius strain ZN2

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: GTH25_RS10895
• Protein ID: WP_075673025.1
• Coordinates: 2331641..2332132 (+)
• Length: 164 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: -
• Locus tag: GTH25_RS10890
• Protein ID: WP_075673024.1
• Coordinates: 2331387..2331653 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GTH25_RS10855	2327048..2327530	+	483	WP_006533151.1	flagellar basal body-associated protein FliL	-
GTH25_RS10860	2327536..2328567	+	1032	WP_023581831.1	flagellar motor switch protein FliM	-
GTH25_RS10865	2328560..2328970	+	411	WP_006533153.1	flagellar motor switch protein FliN	-
GTH25_RS10870	2328974..2329420	+	447	WP_075673022.1	flagellar biosynthetic protein FliO	-
GTH25_RS10875	2329477..2330190	+	714	WP_171455369.1	flagellar type III secretion system pore protein FliP	-
GTH25_RS10880	2330206..2330475	+	270	WP_069367481.1	flagellar biosynthesis protein FliQ	-
GTH25_RS10885	2330481..2331263	+	783	WP_075673023.1	flagellar type III secretion system protein FliR	-
GTH25_RS10890	2331387..2331653	+	267	WP_075673024.1	DUF1778 domain-containing protein	Antitoxin
GTH25_RS10895	2331641..2332132	+	492	WP_075673025.1	GNAT family N-acetyltransferase	Toxin
GTH25_RS10900	2332218..2333162	-	945	WP_087802138.1	flagellar hook-associated protein FlgL	-
GTH25_RS10905	2333187..2334830	-	1644	WP_164530560.1	flagellar hook-associated protein FlgK	-
GTH25_RS10910	2334949..2335935	-	987	WP_099660621.1	flagellar assembly peptidoglycan hydrolase FlgJ	-
GTH25_RS10915	2335935..2337041	-	1107	WP_075673029.1	flagellar basal body P-ring protein FlgI	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (22-150)

Antitoxin

• Vibrio phage ICP1, Orf50 (2-87)

Sequences

Toxin

Protein

• Length: 164 a.a.
• Molecular weight: 18228.15 Da
• Isoelectric Point: 10.3194

>T146026 WP_075673025.1 NZ_CP047349:2331641-2332132 [Proteus terrae subsp. cibarius]
MGKVTAPEPLSNSHEVADFYSSENVLDNWIKQRGLKNQFLGASRTFVVCEKNKKRVVGYYSLATGSVNHTEAMSHIRRNM
PDPIPVIILARLAVDKTFHGKGLGADLLRDAVLRCHHVAENIGVRAIMVHALTENAKHFYLHHGFKASSTQDKILFLALK
KKI

Nucleotide

• Length: 492 bp

>T146026 NZ_CP062717:c3408987-3408613 [Escherichia coli O157:H7]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10111.62 Da
• Isoelectric Point: 4.5256

>AT146026 WP_075673024.1 NZ_CP047349:2331387-2331653 [Proteus terrae subsp. cibarius]
MKADVQLNIRAKESQRALIDTAAEILHKSRTDFILETACQAAEDVILDRRTFNLNDAQYAEFIEIIDAPVDIDPALEKLL
MRKPLWEK

Nucleotide

• Length: 267 bp

>AT146026 NZ_CP062717:c3409408-3409034 [Escherichia coli O157:H7]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA