Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4303768..4305339 Replicon chromosome
Accession NZ_CP047344
Organism Proteus vulgaris strain ZN3

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag GTH24_RS20090 Protein ID WP_164526895.1
Coordinates 4303768..4305081 (-) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag GTH24_RS20095 Protein ID WP_072070485.1
Coordinates 4305082..4305339 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTH24_RS20075 4298986..4302033 + 3048 WP_164526893.1 TonB-dependent receptor -
GTH24_RS20080 4302061..4302855 + 795 WP_164526894.1 energy transducer TonB -
GTH24_RS20085 4302929..4303390 - 462 WP_082151834.1 DUF1097 domain-containing protein -
GTH24_RS20090 4303768..4305081 - 1314 WP_164526895.1 type II toxin-antitoxin system HipA family toxin Toxin
GTH24_RS20095 4305082..4305339 - 258 WP_072070485.1 helix-turn-helix domain-containing protein Antitoxin
GTH24_RS20100 4305488..4306852 - 1365 WP_023583363.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
GTH24_RS20105 4306983..4308623 - 1641 WP_072070483.1 membrane protein insertase YidC -
GTH24_RS20110 4308626..4308886 - 261 WP_072070482.1 membrane protein insertion efficiency factor YidD -
GTH24_RS20115 4308850..4309209 - 360 WP_071788569.1 ribonuclease P protein component -
GTH24_RS20120 4309227..4309370 - 144 WP_036933424.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 49707.73 Da        Isoelectric Point: 6.0122

>T146023 WP_164526895.1 NZ_CP047344:c4305081-4303768 [Proteus vulgaris]
MMSLDVYMNEYYVGIFTKKSSGAHSFQYAEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSSQPFDLLAAVGADTVGALRLLPSGSTPTNIKKIEYNKLDNAELEKILLGYQSNTPLGMLEEYTDFRISIAGAQEKTA
LLLKDDHWCVPHNNTPTTHIIKLPIGVIEGHSYTMDLSDSVENEYLCTLIAKEFDLPVPHCFIIKTKNIKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSAIKYENEGGPGIIDIMNYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSIFI
NQEGRFHLTPLYDIMSIYPNFGGRGLNPRDAKLAMGLQASRGKKYAIEQIFPRHFYQTAEAVGFDPSLMTDILRYFYNEM
DDVIKRVKQQLPNDFPSEISNKILDGMKARSVRLANI

Download         Length: 1314 bp

>T146023 NZ_CP062717:3104089-3104367 [Escherichia coli O157:H7]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9848.40 Da        Isoelectric Point: 10.0139

>AT146023 WP_072070485.1 NZ_CP047344:c4305339-4305082 [Proteus vulgaris]
MIIINAYQLSVHLKDVRLTKKLSQGKVAQKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Download         Length: 258 bp

>AT146023 NZ_CP062717:3103896-3104087 [Escherichia coli O157:H7]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References