Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3883898..3884447 Replicon chromosome
Accession NZ_CP047344
Organism Proteus vulgaris strain ZN3

Toxin (Protein)


Gene name relE Uniprot ID A0A6G6SN87
Locus tag GTH24_RS18210 Protein ID WP_072070950.1
Coordinates 3883898..3884203 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A6G6SPH4
Locus tag GTH24_RS18215 Protein ID WP_072070934.1
Coordinates 3884193..3884447 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTH24_RS18195 3879532..3882366 - 2835 WP_072070931.1 excinuclease ABC subunit UvrA -
GTH24_RS18200 3882619..3883146 + 528 WP_072070932.1 single-stranded DNA-binding protein SSB1 -
GTH24_RS18205 3883334..3883864 + 531 WP_072070933.1 zinc uptake transcriptional repressor Zur -
GTH24_RS18210 3883898..3884203 - 306 WP_072070950.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GTH24_RS18215 3884193..3884447 - 255 WP_072070934.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GTH24_RS18220 3884608..3885219 - 612 WP_072070935.1 transcriptional repressor LexA -
GTH24_RS18225 3885347..3885718 - 372 WP_006536373.1 diacylglycerol kinase -
GTH24_RS18230 3885849..3888332 + 2484 WP_072070936.1 glycerol-3-phosphate 1-O-acyltransferase PlsB -
GTH24_RS18235 3888433..3889287 - 855 WP_072070937.1 4-hydroxybenzoate octaprenyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(2-74)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11937.06 Da        Isoelectric Point: 10.1010

>T146021 WP_072070950.1 NZ_CP047344:c3884203-3883898 [Proteus vulgaris]
IIFNLEFDKRALKEWQKLDQSIKEQFKKKLKKLQENPYIELARLKDDLAGCYKIKLRASGFRLVYQVIDSEVVILVIAVG
KREESKAYSLAEVRIQKNNMY

Download         Length: 306 bp

>T146021 NZ_CP062717:2644596-2644751 [Escherichia coli O157:H7]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTGCGAATCCGAACCGGTCAGACGGAGGTCGCTGTCTTCGTAGACTACGAATCTGAGAAGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9809.27 Da        Isoelectric Point: 4.7064

>AT146021 WP_072070934.1 NZ_CP047344:c3884447-3884193 [Proteus vulgaris]
MTTIQVRVDDELKKEAYQVFEKMNLSPSDAIRLFLRYVSENEKLPFSEVSVVVGELDEDEDILAVVRERLKKPSKRIRVN
IDNL

Download         Length: 255 bp

>AT146021 NZ_CP062717:c2644584-2644526 [Escherichia coli O157:H7]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6G6SN87

Antitoxin

Source ID Structure
AlphaFold DB A0A6G6SPH4

References