Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 3710186..3711927 Replicon chromosome
Accession NZ_CP047344
Organism Proteus vulgaris strain ZN3

Toxin (Protein)


Gene name hipA Uniprot ID A0A6G6SN80
Locus tag GTH24_RS17465 Protein ID WP_072069184.1
Coordinates 3710186..3711559 (+) Length 458 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A6G6SPC9
Locus tag GTH24_RS17470 Protein ID WP_072069029.1
Coordinates 3711556..3711927 (+) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTH24_RS17450 3705853..3706821 - 969 WP_206535565.1 ABC transporter permease subunit -
GTH24_RS17455 3706821..3708404 - 1584 WP_164526759.1 ABC transporter substrate-binding protein -
GTH24_RS17460 3708807..3709796 - 990 WP_072069028.1 glycosyltransferase -
GTH24_RS17465 3710186..3711559 + 1374 WP_072069184.1 type II toxin-antitoxin system HipA family toxin Toxin
GTH24_RS17470 3711556..3711927 + 372 WP_072069029.1 helix-turn-helix domain-containing protein Antitoxin
GTH24_RS17475 3712055..3712555 - 501 WP_072069030.1 hydrogenase maturation peptidase HycI -
GTH24_RS17480 3712552..3712962 - 411 WP_072069031.1 formate hydrogenlyase maturation HycH family protein -
GTH24_RS17485 3712955..3713737 - 783 WP_072069032.1 NADH-quinone oxidoreductase subunit B family protein -
GTH24_RS17490 3713734..3714288 - 555 WP_036934329.1 hydrogenase 4 subunit H -
GTH24_RS17495 3714300..3716033 - 1734 WP_072069033.1 hydrogenase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(174-415)

Antitoxin

Cro/C1-type helix-turn-helix domain

(48-103)


Sequences

Toxin        


Download         Length: 458 a.a.        Molecular weight: 52474.27 Da        Isoelectric Point: 4.7625

>T146020 WP_072069184.1 NZ_CP047344:3710186-3711559 [Proteus vulgaris]
MEKITLQAFIVQEWRDIAIIHFPKHDHALYASKYDITYPITELEYETNYSVDYLYRDDNYAVSINHPVALYFDDNGSPGW
LKFLDDIVPSGASRRYWIQYLDIANLTVEQQNYELLYHGTISPIGNLRVKESLPTPSSLNKALVFTIDDVKNRASDFLDY
AQRKGAAAGGATGAGGEAPKLLLRCSKNEEVWIDTYQDDASNLDKYYLVKFPRGNRSSIDCDILRAEYHFYHELTAMGFN
TISIEGMRLEEGNNYPSLWLPRFDIKIENNEVIRLAMESVYSMLNKAPGTTLYHETAIRELIDKINQSNMVTQFGFQFDT
SDFIIEWVRRDLLNIIFGNSDNHGRNTSFIRYNNAIYLAPIYDFAPMKADPEGIARTTKWNSQNEMGGEYSFINIANSLS
DLIPQEQLLNALKETALQLITLKERLEIRGVPTQILTMPSFGFDFIPNKLERWGLLS

Download         Length: 1374 bp

>T146020 NZ_CP062717:2314358-2314461 [Escherichia coli O157:H7]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 14015.37 Da        Isoelectric Point: 10.4324

>AT146020 WP_072069029.1 NZ_CP047344:3711556-3711927 [Proteus vulgaris]
MNNVNHKSPINTIPVRASKKRQSVATVDRKEVINQTMSQLLFEEISQGEALKILRIKVLGLNQERYAKLIHISRKTLSEI
ENDKGNYSADIINKVFKPFGLKIGLIPYSPHVLLSLLKEHINE

Download         Length: 372 bp

>AT146020 NZ_CP062717:c2314499-2314228 [Escherichia coli O157:H7]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6G6SN80

Antitoxin

Source ID Structure
AlphaFold DB A0A6G6SPC9

References