Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 3641722..3643444 | Replicon | chromosome |
| Accession | NZ_CP047344 | ||
| Organism | Proteus vulgaris strain ZN3 | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | A0A6N4MEU3 |
| Locus tag | GTH24_RS17160 | Protein ID | WP_004249362.1 |
| Coordinates | 3641722..3642660 (-) | Length | 313 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | A0A6G6SM63 |
| Locus tag | GTH24_RS17165 | Protein ID | WP_036973704.1 |
| Coordinates | 3642653..3643444 (-) | Length | 264 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GTH24_RS17140 | 3637663..3638175 | - | 513 | WP_004249367.1 | S26 family signal peptidase | - |
| GTH24_RS17145 | 3638159..3638506 | - | 348 | WP_004249366.1 | hypothetical protein | - |
| GTH24_RS17150 | 3638499..3640898 | - | 2400 | WP_004249365.1 | type IV secretion system protein TraC | - |
| GTH24_RS17155 | 3640898..3641590 | - | 693 | WP_004249363.1 | DsbC family protein | - |
| GTH24_RS17160 | 3641722..3642660 | - | 939 | WP_004249362.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| GTH24_RS17165 | 3642653..3643444 | - | 792 | WP_036973704.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| GTH24_RS17170 | 3643665..3644051 | - | 387 | WP_004249359.1 | hypothetical protein | - |
| GTH24_RS17175 | 3644048..3644620 | - | 573 | WP_004249358.1 | type IV conjugative transfer system lipoprotein TraV | - |
| GTH24_RS17180 | 3644695..3645984 | - | 1290 | WP_004249357.1 | TraB/VirB10 family protein | - |
| GTH24_RS17185 | 3645987..3646883 | - | 897 | WP_004249356.1 | type-F conjugative transfer system secretin TraK | - |
| GTH24_RS17190 | 3646867..3647493 | - | 627 | WP_004249355.1 | type IV conjugative transfer system protein TraE | - |
| GTH24_RS17195 | 3647490..3647771 | - | 282 | WP_004249354.1 | type IV conjugative transfer system protein TraL | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | tet(H) | - | 3534418..3681483 | 147065 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 313 a.a. Molecular weight: 35569.83 Da Isoelectric Point: 5.1159
>T146019 WP_004249362.1 NZ_CP047344:c3642660-3641722 [Proteus vulgaris]
MDKDSPYYKQVSLLIRLLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRNEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSPVATIKIEVSPVARGTLHSAEIMPVQESVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGISREILVGFLTYTLSHPRPINEVMSPNWQHLNEKFQAEFDGMTFEKVECEDLASVRPMMLIELQK
HFTERDHAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE
MDKDSPYYKQVSLLIRLLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRNEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSPVATIKIEVSPVARGTLHSAEIMPVQESVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGISREILVGFLTYTLSHPRPINEVMSPNWQHLNEKFQAEFDGMTFEKVECEDLASVRPMMLIELQK
HFTERDHAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE
Download Length: 939 bp
>T146019 NZ_CP062717:1093265-1093600 [Escherichia coli O157:H7]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
Antitoxin
Download Length: 264 a.a. Molecular weight: 30113.48 Da Isoelectric Point: 9.5097
>AT146019 WP_036973704.1 NZ_CP047344:c3643444-3642653 [Proteus vulgaris]
MSSKINWLIAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLSSGVYYRPNAQGDIKPTWVDAIQALDVQLGVSVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRIDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG
MSSKINWLIAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLSSGVYYRPNAQGDIKPTWVDAIQALDVQLGVSVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRIDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG
Download Length: 792 bp
>AT146019 NZ_CP062717:1093017-1093265 [Escherichia coli O157:H7]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6N4MEU3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6G6SM63 |