Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/GNAT-DUF1778
Location 2534434..2535173 Replicon chromosome
Accession NZ_CP047344
Organism Proteus vulgaris strain ZN3

Toxin (Protein)


Gene name tacT Uniprot ID A0A6G6SNF5
Locus tag GTH24_RS12065 Protein ID WP_072068519.1
Coordinates 2534688..2535173 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A6G6SIM7
Locus tag GTH24_RS12060 Protein ID WP_072068518.1
Coordinates 2534434..2534700 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTH24_RS12025 2530098..2530580 + 483 WP_006533151.1 flagellar basal body-associated protein FliL -
GTH24_RS12030 2530586..2531614 + 1029 WP_072068513.1 flagellar motor switch protein FliM -
GTH24_RS12035 2531607..2532017 + 411 WP_006533153.1 flagellar motor switch protein FliN -
GTH24_RS12040 2532021..2532467 + 447 WP_072068514.1 flagellar biosynthetic protein FliO -
GTH24_RS12045 2532467..2533237 + 771 WP_072068515.1 flagellar type III secretion system pore protein FliP -
GTH24_RS12050 2533253..2533522 + 270 WP_072068516.1 flagellar biosynthesis protein FliQ -
GTH24_RS12055 2533528..2534310 + 783 WP_164526460.1 flagellar type III secretion system protein FliR -
GTH24_RS12060 2534434..2534700 + 267 WP_072068518.1 DUF1778 domain-containing protein Antitoxin
GTH24_RS12065 2534688..2535173 + 486 WP_072068519.1 GNAT family N-acetyltransferase Toxin
GTH24_RS12070 2535268..2536212 - 945 WP_072068520.1 flagellar hook-associated protein FlgL -
GTH24_RS12075 2536244..2537896 - 1653 WP_072068521.1 flagellar hook-associated protein FlgK -
GTH24_RS12080 2538014..2539000 - 987 WP_072068522.1 flagellar assembly peptidoglycan hydrolase FlgJ -
GTH24_RS12085 2539000..2540106 - 1107 WP_072068523.1 flagellar basal body P-ring protein FlgI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(22-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-81)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17951.68 Da        Isoelectric Point: 9.9332

>T146018 WP_072068519.1 NZ_CP047344:2534688-2535173 [Proteus vulgaris]
MGKITAPEPLSNSHEVADFYSSENVLDNWIKQRGLKNQFLGASRTFMVCEKNKKRVVGYYSLATGSVNHTEAISHIRHNM
PDPIPVIILARLAVDKTFHGKGLGADLLRDAVLRCHHVAENIGVRAIMVHALTENAKQFYLHNGFKASSTQENTLFLALK
K

Download         Length: 486 bp

>T146018 NZ_CP062717:946470-946877 [Escherichia coli O157:H7]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10039.56 Da        Isoelectric Point: 4.6437

>AT146018 WP_072068518.1 NZ_CP047344:2534434-2534700 [Proteus vulgaris]
MKADVQLNIRAKGSQRALIDTAAEILHKSRTDFILETACQAAEDVILDRRTFNLNDAQYAEFIEIIDAPVDIDPALEKLL
MRKPLWEK

Download         Length: 267 bp

>AT146018 NZ_CP062717:946223-946489 [Escherichia coli O157:H7]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTATGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCCGATC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6G6SNF5

Antitoxin

Source ID Structure
AlphaFold DB A0A6G6SIM7

References