Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1445148..1445793 Replicon chromosome
Accession NZ_CP047344
Organism Proteus vulgaris strain ZN3

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag GTH24_RS06565 Protein ID WP_164526097.1
Coordinates 1445608..1445793 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag GTH24_RS06560 Protein ID WP_164526096.1
Coordinates 1445148..1445561 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTH24_RS06540 1440626..1441207 - 582 WP_072069983.1 hypothetical protein -
GTH24_RS06545 1442229..1443455 - 1227 WP_164526095.1 dNTP triphosphohydrolase -
GTH24_RS06550 1443687..1443881 - 195 Protein_1252 recombinase -
GTH24_RS06555 1443877..1445105 + 1229 Protein_1253 phage terminase large subunit -
GTH24_RS06560 1445148..1445561 - 414 WP_164526096.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GTH24_RS06565 1445608..1445793 - 186 WP_164526097.1 type II toxin-antitoxin system HicA family toxin Toxin
GTH24_RS06570 1445903..1446064 + 162 WP_164526098.1 hypothetical protein -
GTH24_RS06575 1446088..1446348 + 261 Protein_1257 hypothetical protein -
GTH24_RS06580 1447600..1448253 - 654 WP_164526099.1 type A chloramphenicol O-acetyltransferase -
GTH24_RS06585 1448363..1448593 - 231 WP_164526100.1 DNA polymerase III subunit theta -
GTH24_RS06590 1448954..1449613 - 660 WP_164526101.1 hypothetical protein -
GTH24_RS06595 1449613..1450038 - 426 WP_164526102.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage cat - 1443687..1499097 55410


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 7035.28 Da        Isoelectric Point: 10.9659

>T146017 WP_164526097.1 NZ_CP047344:c1445793-1445608 [Proteus vulgaris]
MKSSELIKLLEKNGWVLDRIKGSHHQFTHPDFSFVVTVPHPRKDLKKGTLNQIIKSAKLKN

Download         Length: 186 bp

>T146017 NZ_CP062717:751356-751670 [Escherichia coli O157:H7]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTAGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTTTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15237.99 Da        Isoelectric Point: 4.3830

>AT146017 WP_164526096.1 NZ_CP047344:c1445561-1445148 [Proteus vulgaris]
MLYPAFIEIDEDGSASGWFPDIDGCIFAGDSIEEAHADAKSAIDAHFELLSEKGLDIPSPKSQQEHLINSTGDYNNGIWL
LVDVDMDKYDGRAERINITLPHRLLSRIDTIVKTNPEYGSRSGFIATATRKELQKNI

Download         Length: 414 bp

>AT146017 NZ_CP062717:751667-752083 [Escherichia coli O157:H7]
ATGATTGCGATTGCCGACATCTTGCATGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACATCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTACTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References