Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 12269..12867 Replicon chromosome
Accession NZ_CP047344
Organism Proteus vulgaris strain ZN3

Toxin (Protein)


Gene name doc Uniprot ID A0A6G6SCV0
Locus tag GTH24_RS00055 Protein ID WP_072070472.1
Coordinates 12269..12649 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A6G6SCZ1
Locus tag GTH24_RS00060 Protein ID WP_072070471.1
Coordinates 12646..12867 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTH24_RS00030 7724..8293 + 570 WP_072070476.1 methyltransferase -
GTH24_RS00035 8349..9836 - 1488 WP_164525804.1 PLP-dependent aminotransferase family protein -
GTH24_RS00040 9964..10422 + 459 WP_072070475.1 GNAT family N-acetyltransferase -
GTH24_RS00045 10516..11253 - 738 WP_164525805.1 sel1 repeat family protein -
GTH24_RS00050 11359..12258 + 900 WP_164525806.1 N-acetylmuramic acid 6-phosphate etherase -
GTH24_RS00055 12269..12649 - 381 WP_072070472.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
GTH24_RS00060 12646..12867 - 222 WP_072070471.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
GTH24_RS00065 13026..13889 - 864 WP_115351316.1 YicC family protein -
GTH24_RS00070 14015..14731 + 717 WP_072070469.1 ribonuclease PH -
GTH24_RS00075 14813..15457 + 645 WP_072070468.1 orotate phosphoribosyltransferase -
GTH24_RS00080 15765..16367 - 603 WP_072070467.1 nucleoid occlusion factor SlmA -
GTH24_RS00085 16480..16938 - 459 WP_072070466.1 dUTP diphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(4-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14283.27 Da        Isoelectric Point: 7.3135

>T146016 WP_072070472.1 NZ_CP047344:c12649-12269 [Proteus vulgaris]
MNWVSAKEVIAFHDKILKQLPGVAGMSEPGRAEALIYRVQNRTHYEGITDIYELAATYWIAISRGHIFNDGNKRTAFFVT
MTFLYRNGIKIIDIDDTLENLTVDAATGAKNSQQLAQYLRKLSDKD

Download         Length: 381 bp

>T146016 NZ_CP062717:c708870-708406 [Escherichia coli O157:H7]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8221.23 Da        Isoelectric Point: 6.6412

>AT146016 WP_072070471.1 NZ_CP047344:c12867-12646 [Proteus vulgaris]
MHTYTSTQARAHISEVLDTAIHGEPVEITRRDGTSAVVISKVEFEAYQNAKLDAEFDIIMQRHGHTIKALTNR

Download         Length: 222 bp

>AT146016 NZ_CP062717:c709205-708870 [Escherichia coli O157:H7]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAGCAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATACAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6G6SCV0

Antitoxin

Source ID Structure
AlphaFold DB A0A6G6SCZ1

References