Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 29888..30410 Replicon plasmid p2019036D-35kb
Accession NZ_CP047339
Organism Klebsiella pneumoniae strain 2019036D

Toxin (Protein)


Gene name relE Uniprot ID D0QMR1
Locus tag GTH21_RS29410 Protein ID WP_000220561.1
Coordinates 30129..30410 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag GTH21_RS29405 Protein ID WP_000121743.1
Coordinates 29888..30139 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTH21_RS29385 26011..26433 - 423 WP_179292036.1 DNA distortion polypeptide 3 -
GTH21_RS29390 26501..26947 - 447 WP_001074384.1 hypothetical protein -
GTH21_RS29395 26951..27793 - 843 WP_000435064.1 replication initiation protein -
GTH21_RS29400 27814..28653 - 840 WP_024129959.1 replication initiation protein -
GTH21_RS29405 29888..30139 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
GTH21_RS29410 30129..30410 + 282 WP_000220561.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GTH21_RS29415 30649..30741 - 93 Protein_32 IS6 family transposase -
GTH21_RS29420 30907..32106 - 1200 WP_000948429.1 IS91 family transposase -
GTH21_RS29425 32116..32304 - 189 WP_000957857.1 hypothetical protein -
GTH21_RS29430 32424..33854 + 1431 Protein_35 IS4-like element IS50R family transposase -
GTH21_RS29435 33883..34677 + 795 WP_000572405.1 aminoglycoside O-phosphotransferase APH(3')-IIa -
GTH21_RS29440 34698..34934 + 237 Protein_37 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaCTX-M-55 / blaTEM-1B / aph(3')-Ia / aph(3')-IIa - 1..35955 35955


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11023.86 Da        Isoelectric Point: 10.5938

>T146008 WP_000220561.1 NZ_CP047339:30129-30410 [Klebsiella pneumoniae]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADMR

Download         Length: 282 bp

>T146008 NZ_CP062716:2065-2340 [Escherichia coli O157:H7]
ATGGAACTGAAGTGGAGCAGTAAAGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTAGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGGGAACAGTTATTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT146008 WP_000121743.1 NZ_CP047339:29888-30139 [Klebsiella pneumoniae]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT146008 NZ_CP062716:1781-2065 [Escherichia coli O157:H7]
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTCATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGTTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATTGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5I302

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References