Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3966933..3967774 Replicon chromosome
Accession NZ_CP047336
Organism Klebsiella pneumoniae strain 2019036D

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1M0WJM1
Locus tag GTH21_RS19960 Protein ID WP_000854822.1
Coordinates 3966933..3967316 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1M0CWL2
Locus tag GTH21_RS19965 Protein ID WP_053271974.1
Coordinates 3967406..3967774 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTH21_RS19930 3962557..3964398 + 1842 WP_004174339.1 RNA polymerase sigma factor RpoD -
GTH21_RS19935 3964498..3965004 - 507 WP_002917636.1 G/U mismatch-specific DNA glycosylase -
GTH21_RS19945 3965303..3966148 - 846 WP_001280435.1 DUF4942 domain-containing protein -
GTH21_RS19950 3966245..3966487 - 243 WP_166635458.1 DUF957 domain-containing protein -
GTH21_RS19955 3966454..3966942 - 489 WP_001177592.1 hypothetical protein -
GTH21_RS19960 3966933..3967316 - 384 WP_000854822.1 type IV toxin-antitoxin system toxin CbtA Toxin
GTH21_RS19965 3967406..3967774 - 369 WP_053271974.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
GTH21_RS19970 3967854..3968075 - 222 WP_000692312.1 DUF987 domain-containing protein -
GTH21_RS19975 3968144..3968620 - 477 WP_001186747.1 RadC family protein -
GTH21_RS19980 3968635..3969120 - 486 WP_000214317.1 antirestriction protein -
GTH21_RS19985 3969211..3970029 - 819 WP_001234702.1 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14295.32 Da        Isoelectric Point: 8.2830

>T145998 WP_000854822.1 NZ_CP047336:c3967316-3966933 [Klebsiella pneumoniae]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHQESKRCN

Download         Length: 384 bp

>T145998 NZ_CP062715:c3590801-3590646 [Escherichia coli O157:H7]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAGTCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13679.41 Da        Isoelectric Point: 6.4758

>AT145998 WP_053271974.1 NZ_CP047336:c3967774-3967406 [Klebsiella pneumoniae]
VSDTFSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLTDRAGIRGRFSDADANHLDQAFPLLMKQLELMLTSS
ELNPHRQNTVTLYVKGLTCHADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT145998 NZ_CP062715:3590813-3590871 [Escherichia coli O157:H7]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M0WJM1

Antitoxin

Source ID Structure
AlphaFold DB A0A1M0CWL2

References