Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3760341..3760998 Replicon chromosome
Accession NZ_CP047336
Organism Klebsiella pneumoniae strain 2019036D

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag GTH21_RS18840 Protein ID WP_002916310.1
Coordinates 3760341..3760751 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag GTH21_RS18845 Protein ID WP_002916312.1
Coordinates 3760732..3760998 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTH21_RS18820 3756341..3758074 - 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -
GTH21_RS18825 3758080..3758793 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GTH21_RS18830 3758816..3759712 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
GTH21_RS18835 3759813..3760334 + 522 WP_002916308.1 flavodoxin FldB -
GTH21_RS18840 3760341..3760751 - 411 WP_002916310.1 protein YgfX Toxin
GTH21_RS18845 3760732..3760998 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
GTH21_RS18850 3761244..3762227 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
GTH21_RS18855 3762378..3763037 - 660 WP_002916317.1 hemolysin III family protein -
GTH21_RS18860 3763201..3763512 - 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
GTH21_RS18865 3763562..3764290 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
GTH21_RS18870 3764409..3765842 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T145996 WP_002916310.1 NZ_CP047336:c3760751-3760341 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T145996 NZ_CP062715:3130209-3130316 [Escherichia coli O157:H7]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT145996 WP_002916312.1 NZ_CP047336:c3760998-3760732 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT145996 NZ_CP062715:c3130156-3130095 [Escherichia coli O157:H7]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References