Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 722295..722824 Replicon chromosome
Accession NZ_CP047326
Organism Enterococcus faecium strain 116

Toxin (Protein)


Gene name relE Uniprot ID C9B8W9
Locus tag GST81_RS03410 Protein ID WP_002294198.1
Coordinates 722295..722561 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C9B8W8
Locus tag GST81_RS03415 Protein ID WP_002294199.1
Coordinates 722561..722824 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GST81_RS03380 (GST81_03360) 717662..718837 + 1176 WP_002294192.1 betaine/proline/choline family ABC transporter ATP-binding protein -
GST81_RS03385 (GST81_03365) 718841..719482 + 642 WP_002293405.1 ABC transporter permease -
GST81_RS03390 (GST81_03370) 719479..720396 + 918 WP_002294193.1 osmoprotectant ABC transporter substrate-binding protein -
GST81_RS03395 (GST81_03375) 720393..721064 + 672 WP_002319469.1 ABC transporter permease -
GST81_RS03400 (GST81_03380) 721376..721543 - 168 WP_002294195.1 hypothetical protein -
GST81_RS03405 (GST81_03385) 721606..722094 - 489 WP_002294196.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
GST81_RS03410 (GST81_03390) 722295..722561 - 267 WP_002294198.1 Txe/YoeB family addiction module toxin Toxin
GST81_RS03415 (GST81_03395) 722561..722824 - 264 WP_002294199.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GST81_RS13495 723164..723292 - 129 WP_002294200.1 hypothetical protein -
GST81_RS03420 (GST81_03400) 723299..723484 + 186 WP_002294201.1 hypothetical protein -
GST81_RS03425 (GST81_03405) 723626..725449 - 1824 WP_002294202.1 APC family permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(22-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10646.11 Da        Isoelectric Point: 9.9931

>T145983 WP_002294198.1 NZ_CP047326:c722561-722295 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQSNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

>T145983 NZ_CP062715:365363-365638 [Escherichia coli O157:H7]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGC
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10016.03 Da        Isoelectric Point: 4.1207

>AT145983 WP_002294199.1 NZ_CP047326:c722824-722561 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
DIDWEAL

Download         Length: 264 bp

>AT145983 NZ_CP062715:365635-365994 [Escherichia coli O157:H7]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FMA0

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZU84

References