Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2038433..2038910 Replicon chromosome
Accession NZ_CP047321
Organism Staphylococcus aureus strain RJ1267

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag GSF72_RS10385 Protein ID WP_000052078.1
Coordinates 2038722..2038910 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag GSF72_RS10380 Protein ID WP_001059690.1
Coordinates 2038433..2038693 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GSF72_RS10345 2033826..2034542 - 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -
GSF72_RS10350 2034690..2035112 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
GSF72_RS10355 2035511..2036005 + 495 WP_048665416.1 GNAT family N-acetyltransferase -
GSF72_RS10360 2036160..2036777 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
GSF72_RS10365 2036850..2037431 - 582 WP_001140693.1 phosphoglycerate mutase family protein -
GSF72_RS10370 2037656..2037892 + 237 WP_000368687.1 hypothetical protein -
GSF72_RS10375 2037889..2038092 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
GSF72_RS10380 2038433..2038693 + 261 WP_001059690.1 hypothetical protein Antitoxin
GSF72_RS10385 2038722..2038910 + 189 WP_000052078.1 hypothetical protein Toxin
GSF72_RS10390 2039098..2039667 + 570 WP_001106654.1 hypothetical protein -
GSF72_RS10395 2039755..2040039 + 285 WP_001004395.1 hypothetical protein -
GSF72_RS10400 2040101..2040319 + 219 WP_000005886.1 hypothetical protein -
GSF72_RS10405 2040815..2041015 - 201 WP_001059082.1 cold-shock protein -
GSF72_RS10410 2041372..2042058 - 687 WP_001548082.1 thermonuclease family protein -
GSF72_RS10415 2042400..2042870 - 471 WP_000824472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T145970 WP_000052078.1 NZ_CP047321:2038722-2038910 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T145970 NZ_CP062713:3593123-3593410 [Escherichia coli O157:H7]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT145970 WP_001059690.1 NZ_CP047321:2038433-2038693 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT145970 NZ_CP062713:3592932-3593123 [Escherichia coli O157:H7]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References