Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 817318..817847 Replicon chromosome
Accession NZ_CP047321
Organism Staphylococcus aureus strain RJ1267

Toxin (Protein)


Gene name TscT Uniprot ID K7ZRX2
Locus tag GSF72_RS04095 Protein ID WP_001103933.1
Coordinates 817530..817847 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID A0A6B0BJC0
Locus tag GSF72_RS04090 Protein ID WP_001058487.1
Coordinates 817318..817527 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GSF72_RS04055 812549..812833 + 285 WP_000917289.1 co-chaperone GroES -
GSF72_RS04060 812909..814525 + 1617 WP_000240645.1 chaperonin GroEL -
GSF72_RS04065 814594..815766 - 1173 WP_000179353.1 site-specific integrase -
GSF72_RS04070 815780..816502 - 723 WP_000672427.1 helix-turn-helix domain-containing protein -
GSF72_RS04075 816655..816861 + 207 WP_000794657.1 helix-turn-helix transcriptional regulator -
GSF72_RS04080 816865..817182 + 318 WP_000481968.1 helix-turn-helix domain-containing protein -
GSF72_RS04085 817179..817325 + 147 WP_000708434.1 hypothetical protein -
GSF72_RS04090 817318..817527 + 210 WP_001058487.1 hypothetical protein Antitoxin
GSF72_RS04095 817530..817847 + 318 WP_001103933.1 DUF1474 family protein Toxin
GSF72_RS04100 817914..818783 + 870 WP_001002699.1 primase alpha helix C-terminal domain-containing protein -
GSF72_RS04105 818800..820269 + 1470 WP_001838755.1 virulence-associated E family protein -
GSF72_RS04110 820555..820917 + 363 WP_001039169.1 hypothetical protein -
GSF72_RS04115 820919..821203 + 285 WP_000998179.1 hypothetical protein -
GSF72_RS04120 821200..821841 + 642 WP_001019811.1 hypothetical protein -
GSF72_RS04125 822376..822717 + 342 WP_001190614.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - groEL 806643..826771 20128


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12511.13 Da        Isoelectric Point: 4.6364

>T145961 WP_001103933.1 NZ_CP047321:817530-817847 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKEKINDVAIKHGWFVEDKFVKNELETKQEHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASSENFGEESDDAKKLKITE

Download         Length: 318 bp

>T145961 NZ_CP062713:1094580-1094915 [Escherichia coli O157:H7]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8228.24 Da        Isoelectric Point: 4.1682

>AT145961 WP_001058487.1 NZ_CP047321:817318-817527 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSIMNNFESYEHTEYVDGIEVVSEISPEKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT145961 NZ_CP062713:1094332-1094580 [Escherichia coli O157:H7]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K7ZRX2

Antitoxin

Source ID Structure
AlphaFold DB A0A6B0BJC0

References