Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-YefM
Location 2429822..2430348 Replicon chromosome
Accession NZ_CP047318
Organism Streptomyces sp. HM190

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag GSY65_RS10165 Protein ID WP_159767020.1
Coordinates 2430091..2430348 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag GSY65_RS10160 Protein ID WP_159767019.1
Coordinates 2429822..2430094 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GSY65_RS10145 2426540..2426890 + 351 WP_159767017.1 hypothetical protein -
GSY65_RS10150 2427012..2427674 - 663 Protein_2010 hypothetical protein -
GSY65_RS10155 2428064..2429416 + 1353 WP_159767018.1 recombinase -
GSY65_RS10160 2429822..2430094 + 273 WP_159767019.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GSY65_RS10165 2430091..2430348 + 258 WP_159767020.1 Txe/YoeB family addiction module toxin Toxin
GSY65_RS10170 2430389..2431045 - 657 WP_159767021.1 class I SAM-dependent methyltransferase -
GSY65_RS10175 2431115..2431615 - 501 WP_159767022.1 hypothetical protein -
GSY65_RS10180 2431803..2432009 - 207 WP_159767023.1 hypothetical protein -
GSY65_RS10185 2432182..2432937 + 756 WP_159767024.1 hypothetical protein -
GSY65_RS10190 2432957..2433802 + 846 WP_159767025.1 helix-turn-helix transcriptional regulator -
GSY65_RS10195 2434001..2434204 - 204 WP_159767026.1 DUF397 domain-containing protein -
GSY65_RS10200 2434201..2435031 - 831 WP_159767027.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-71)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10107.60 Da        Isoelectric Point: 9.8728

>T145950 WP_159767020.1 NZ_CP047318:2430091-2430348 [Streptomyces sp. HM190]
VRSVRCDPAGWEDFLFWLGSDRAMARRITRLIAEIQRTPFTGIGKPEPLKGDLSGYWSRRIDDEHRLVYRVDEKEVKILK
ARYHY

Download         Length: 258 bp

>T145950 NZ_CP062712:2065-2340 [Escherichia coli O157:H7]
ATGGAACTGAAGTGGAGCAGTAAAGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTAGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGGGAACAGTTATTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9892.07 Da        Isoelectric Point: 4.6290

>AT145950 WP_159767019.1 NZ_CP047318:2429822-2430094 [Streptomyces sp. HM190]
MTMSASEARKDLFPLIKRVNDDHTPVRISSKSGDAVLMSADDYDSWQETVHLLRSPANARSLMEALARDRAGETVVTRTM
AELDELAGDG

Download         Length: 273 bp

>AT145950 NZ_CP062712:1781-2065 [Escherichia coli O157:H7]
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTCATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGTTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATTGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References