Detailed information of TA system TA145950

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-YefM
• Location: 2429822..2430348
• Replicon: chromosome
• Accession: NZ_CP047318
• Organism: Streptomyces sp. HM190

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GSY65_RS10165
• Protein ID: WP_159767020.1
• Coordinates: 2430091..2430348 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: GSY65_RS10160
• Protein ID: WP_159767019.1
• Coordinates: 2429822..2430094 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GSY65_RS10145	2426540..2426890	+	351	WP_159767017.1	hypothetical protein	-
GSY65_RS10150	2427012..2427674	-	663	Protein_2010	hypothetical protein	-
GSY65_RS10155	2428064..2429416	+	1353	WP_159767018.1	recombinase	-
GSY65_RS10160	2429822..2430094	+	273	WP_159767019.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GSY65_RS10165	2430091..2430348	+	258	WP_159767020.1	Txe/YoeB family addiction module toxin	Toxin
GSY65_RS10170	2430389..2431045	-	657	WP_159767021.1	class I SAM-dependent methyltransferase	-
GSY65_RS10175	2431115..2431615	-	501	WP_159767022.1	hypothetical protein	-
GSY65_RS10180	2431803..2432009	-	207	WP_159767023.1	hypothetical protein	-
GSY65_RS10185	2432182..2432937	+	756	WP_159767024.1	hypothetical protein	-
GSY65_RS10190	2432957..2433802	+	846	WP_159767025.1	helix-turn-helix transcriptional regulator	-
GSY65_RS10195	2434001..2434204	-	204	WP_159767026.1	DUF397 domain-containing protein	-
GSY65_RS10200	2434201..2435031	-	831	WP_159767027.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-71)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10107.60 Da
• Isoelectric Point: 9.8728

>T145950 WP_159767020.1 NZ_CP047318:2430091-2430348 [Streptomyces sp. HM190]
VRSVRCDPAGWEDFLFWLGSDRAMARRITRLIAEIQRTPFTGIGKPEPLKGDLSGYWSRRIDDEHRLVYRVDEKEVKILK
ARYHY

Nucleotide

• Length: 258 bp

>T145950 NZ_CP062712:2065-2340 [Escherichia coli O157:H7]
ATGGAACTGAAGTGGAGCAGTAAAGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTAGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGGGAACAGTTATTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 9892.07 Da
• Isoelectric Point: 4.6290

>AT145950 WP_159767019.1 NZ_CP047318:2429822-2430094 [Streptomyces sp. HM190]
MTMSASEARKDLFPLIKRVNDDHTPVRISSKSGDAVLMSADDYDSWQETVHLLRSPANARSLMEALARDRAGETVVTRTM
AELDELAGDG

Nucleotide

• Length: 273 bp

>AT145950 NZ_CP062712:1781-2065 [Escherichia coli O157:H7]
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTCATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGTTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATTGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA