Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 80236..80831 Replicon plasmid pwszb
Accession NZ_CP047317
Organism Burkholderia glumae AU6208

Toxin (Protein)


Gene name chpB Uniprot ID C5AN78
Locus tag GQR88_RS28580 Protein ID WP_012734107.1
Coordinates 80481..80831 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID C5AN79
Locus tag GQR88_RS28575 Protein ID WP_012734108.1
Coordinates 80236..80487 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQR88_RS28540 75415..75903 + 489 WP_012732893.1 GNAT family N-acetyltransferase -
GQR88_RS28545 76419..76703 + 285 WP_017424110.1 hypothetical protein -
GQR88_RS28550 76716..76955 + 240 WP_017424111.1 hypothetical protein -
GQR88_RS28555 76952..77287 + 336 WP_159372738.1 hypothetical protein -
GQR88_RS28560 77284..77625 + 342 WP_017424113.1 hypothetical protein -
GQR88_RS28565 77628..79463 + 1836 WP_159372739.1 site-specific integrase -
GQR88_RS28570 79548..79973 + 426 WP_017425516.1 hypothetical protein -
GQR88_RS28575 80236..80487 + 252 WP_012734108.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
GQR88_RS28580 80481..80831 + 351 WP_012734107.1 type II toxin-antitoxin system ChpB family toxin Toxin
GQR88_RS28585 80890..81084 + 195 WP_124837685.1 hypothetical protein -
GQR88_RS28590 81234..81455 + 222 WP_017433768.1 hypothetical protein -
GQR88_RS28595 81677..82141 + 465 WP_012734106.1 Lrp/AsnC family transcriptional regulator -
GQR88_RS28600 82481..84829 + 2349 WP_039205065.1 TonB-dependent receptor -
GQR88_RS28605 84819..85601 + 783 Protein_83 TonB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..122067 122067


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

Antitoxin PemI-like

(1-83)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12389.37 Da        Isoelectric Point: 8.8909

>T145949 WP_012734107.1 NZ_CP047317:80481-80831 [Burkholderia glumae AU6208]
MVKRVKFERGDIVRVSLSPTVGREQQGDFRPALVLSPAAFNALGVALVAPITQGGEFARFAGFAVPLSGSGTETQGVALV
NMVRMLDLEGRGARKIERAPVEVVEDALARLQTIIE

Download         Length: 351 bp

>T145949 NZ_CP062711:c5060537-5060364 [Escherichia coli O157:H7]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 8940.31 Da        Isoelectric Point: 6.2420

>AT145949 WP_012734108.1 NZ_CP047317:80236-80487 [Burkholderia glumae AU6208]
MELKIQKWGNSAAVRLPSVLLEQINASVGGSLNADVRPDGVLLTPARRKYALDDLVAQCDTKAPVPADMAAWGEIKPVGR
EAW

Download         Length: 252 bp

>AT145949 NZ_CP062711:c5060861-5060565 [Escherichia coli O157:H7]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A246MF70

Antitoxin

Source ID Structure
AlphaFold DB A0A246MFN5

References