Detailed information of TA system TA145947

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 1112717..1113492
• Replicon: chromosome
• Accession: NZ_CP047316
• Organism: Burkholderia glumae AU6208

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: -
• Locus tag: GQR88_RS21605
• Protein ID: WP_017423245.1
• Coordinates: 1112995..1113492 (+)
• Length: 166 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: -
• Locus tag: GQR88_RS21600
• Protein ID: WP_017423246.1
• Coordinates: 1112717..1112998 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GQR88_RS21595	1112024..1112461	+	438	WP_159372664.1	SMI1/KNR4 family protein	-
GQR88_RS21600	1112717..1112998	+	282	WP_017423246.1	DUF1778 domain-containing protein	Antitoxin
GQR88_RS21605	1112995..1113492	+	498	WP_017423245.1	GNAT family N-acetyltransferase	Toxin
GQR88_RS21610	1113573..1114055	+	483	WP_100556488.1	ProQ activator of osmoprotectant transporter prop	-
GQR88_RS21615	1114434..1115375	+	942	Protein_942	RHS domain-containing protein	-
GQR88_RS21620	1115387..1116202	-	816	Protein_943	IS5 family transposase	-
GQR88_RS21625	1116403..1116687	+	285	WP_153478924.1	hypothetical protein	-
GQR88_RS21630	1116810..1117355	+	546	Protein_945	IS3 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1100084..1125030	24946
	-	flank	IS/Tn	-	-	1116837..1117379	542

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (44-144)

Antitoxin

• Vibrio phage ICP1, Orf50 (10-84)

Sequences

Toxin

Protein

• Length: 166 a.a.
• Molecular weight: 17606.19 Da
• Isoelectric Point: 9.6894

>T145947 WP_017423245.1 NZ_CP047316:1112995-1113492 [Burkholderia glumae AU6208]
MTGWRAPEPLSDAHGLDDFDSGVASLDTWLKRRALANQRSGASRTFVATRDGRVGAYYALASGAVTLEVAPGRFRRNMPD
PIPVVVLGRLAVDRAHQGIGVGRALVRDAGLRVLHAAAAIGIRSLIVHALSDSAKAFYERVGFEASPLDPMLLLITLADL
EHALS

Nucleotide

• Length: 498 bp

>T145947 NZ_CP062711:4829169-4829510 [Escherichia coli O157:H7]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10082.37 Da
• Isoelectric Point: 7.0104

>AT145947 WP_017423246.1 NZ_CP047316:1112717-1112998 [Burkholderia glumae AU6208]
MASTTPRDTLNLRIRPDDRSLIDRAAAAAHKTRTDFVLDAARAAAEQTLLDQVVLSAEPQAYAAFLARLDAPAQPNAALR
QTMQTRAPWDPAA

Nucleotide

• Length: 282 bp

>AT145947 NZ_CP062711:c4829174-4829098 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT