Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 1093113..1093703 Replicon chromosome
Accession NZ_CP047315
Organism Burkholderia glumae AU6208

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag GQR88_RS05105 Protein ID WP_017425105.1
Coordinates 1093407..1093703 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag GQR88_RS05100 Protein ID WP_017425106.1
Coordinates 1093113..1093403 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQR88_RS05070 1088624..1089016 + 393 WP_157808587.1 hypothetical protein -
GQR88_RS05075 1089053..1090024 + 972 WP_157808588.1 hypothetical protein -
GQR88_RS05080 1090136..1090480 - 345 WP_157808589.1 hypothetical protein -
GQR88_RS05085 1090701..1091237 - 537 WP_157808590.1 hypothetical protein -
GQR88_RS05090 1091257..1091931 - 675 WP_100555831.1 DUF4145 domain-containing protein -
GQR88_RS05095 1092821..1093108 - 288 WP_017425107.1 helix-turn-helix domain-containing protein -
GQR88_RS05100 1093113..1093403 - 291 WP_017425106.1 putative addiction module antidote protein Antitoxin
GQR88_RS05105 1093407..1093703 - 297 WP_017425105.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GQR88_RS05110 1094160..1094669 + 510 WP_017425104.1 energy transducer TonB -
GQR88_RS05115 1095137..1096447 + 1311 WP_100555832.1 MHS family MFS transporter -
GQR88_RS05120 1096633..1098261 + 1629 WP_100555833.1 chloride channel protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1069091..1096447 27356


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-91)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10888.50 Da        Isoelectric Point: 9.5718

>T145946 WP_017425105.1 NZ_CP047315:c1093703-1093407 [Burkholderia glumae AU6208]
MIELRQTSVFSDWLRALKDVRGAAKIQVRIDRLLDGNPGDSKSVGGGVMEMRIDYGPGYRVYFTQKRGVFVLLLCGGDKS
SQSKDIARAHELASELKD

Download         Length: 297 bp

>T145946 NZ_CP062711:c4713316-4713002 [Escherichia coli O157:H7]
ATGCAATTTACGGTATACCGCAGTCGCAGTAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGTGATTAATCGCCGTATTGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10537.97 Da        Isoelectric Point: 5.1299

>AT145946 WP_017425106.1 NZ_CP047315:c1093403-1093113 [Burkholderia glumae AU6208]
MTVKVTPYDVADYLKTEEQMQAYLEEAFSEAGDDAAFIARAIGNVARARGMTKVAQDSGLSRESLYKALSGERSPDFSTV
LKVLRSLGLRLHPEVV

Download         Length: 291 bp

>AT145946 NZ_CP062711:c4713552-4713319 [Escherichia coli O157:H7]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CTGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References