Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3685894..3686514 Replicon chromosome
Accession NZ_CP047307
Organism Citrobacter freundii strain L75

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag GJV84_RS17690 Protein ID WP_002892050.1
Coordinates 3686296..3686514 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag GJV84_RS17685 Protein ID WP_003021733.1
Coordinates 3685894..3686268 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJV84_RS17675 3681040..3682233 + 1194 WP_003835922.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
GJV84_RS17680 3682256..3685405 + 3150 WP_003021736.1 multidrug efflux RND transporter permease subunit -
GJV84_RS17685 3685894..3686268 + 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
GJV84_RS17690 3686296..3686514 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
GJV84_RS17695 3686821..3687372 + 552 WP_032936967.1 maltose O-acetyltransferase -
GJV84_RS17700 3687489..3687959 + 471 WP_003021724.1 YlaC family protein -
GJV84_RS17705 3688038..3688178 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
GJV84_RS17710 3688180..3688440 - 261 WP_003021719.1 type B 50S ribosomal protein L31 -
GJV84_RS17715 3688629..3690181 + 1553 Protein_3466 EAL domain-containing protein -
GJV84_RS17720 3690233..3690586 - 354 WP_003831033.1 DUF1428 family protein -
GJV84_RS17725 3690651..3691280 - 630 WP_003021707.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T145933 WP_002892050.1 NZ_CP047307:3686296-3686514 [Citrobacter freundii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T145933 NZ_CP062711:2364680-2364783 [Escherichia coli O157:H7]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT145933 WP_003021733.1 NZ_CP047307:3685894-3686268 [Citrobacter freundii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT145933 NZ_CP062711:c2364821-2364550 [Escherichia coli O157:H7]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References