Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 396787..397315 Replicon chromosome
Accession NZ_CP047306
Organism Vibrio cholerae O37 strain ATCC 25872

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag GTH07_RS15385 Protein ID WP_000221352.1
Coordinates 396787..397077 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag GTH07_RS15390 Protein ID WP_000213183.1
Coordinates 397067..397315 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTH07_RS15345 392344..392469 + 126 WP_001944767.1 DUF645 family protein -
GTH07_RS18705 392432..392548 + 117 WP_001889170.1 hypothetical protein -
GTH07_RS15355 (GTH07_15420) 392736..393740 + 1005 WP_000964925.1 LD-carboxypeptidase -
GTH07_RS15360 (GTH07_15425) 393893..394339 + 447 WP_000128977.1 hypothetical protein -
GTH07_RS15365 (GTH07_15430) 394459..395388 + 930 WP_000335802.1 hypothetical protein -
GTH07_RS15370 (GTH07_15435) 395385..395495 + 111 WP_071917832.1 DUF3265 domain-containing protein -
GTH07_RS15375 (GTH07_15440) 395523..395999 + 477 WP_001047180.1 GNAT family N-acetyltransferase -
GTH07_RS15380 (GTH07_15445) 396190..396651 + 462 WP_001903091.1 lipocalin family protein -
GTH07_RS15385 (GTH07_15450) 396787..397077 - 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GTH07_RS15390 (GTH07_15455) 397067..397315 - 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GTH07_RS15395 (GTH07_15460) 397886..398539 + 654 WP_000036957.1 site-specific DNA-methyltransferase -
GTH07_RS15400 (GTH07_15465) 398811..399236 + 426 WP_000415748.1 hypothetical protein -
GTH07_RS15405 (GTH07_15470) 399444..399839 + 396 WP_000649527.1 DUF3465 domain-containing protein -
GTH07_RS15410 (GTH07_15475) 399990..400520 + 531 WP_000415563.1 hypothetical protein -
GTH07_RS15415 (GTH07_15480) 400658..401158 + 501 WP_000789723.1 hypothetical protein -
GTH07_RS15420 (GTH07_15485) 401314..401712 + 399 WP_001882293.1 hypothetical protein -
GTH07_RS15425 (GTH07_15490) 401812..402276 - 465 WP_000140244.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 307620..433724 126104
- inside Integron - - 312700..433348 120648


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T145910 WP_000221352.1 NZ_CP047306:c397077-396787 [Vibrio cholerae O37]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T145910 NZ_CP062708:3594436-3594723 [Escherichia coli O157:H7]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT145910 WP_000213183.1 NZ_CP047306:c397315-397067 [Vibrio cholerae O37]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT145910 NZ_CP062708:3594245-3594436 [Escherichia coli O157:H7]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H9L4R3

Antitoxin

Source ID Structure
AlphaFold DB A0A366A3W8

References