145909

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 381629..382176 Replicon chromosome
Accession NZ_CP047306
Organism Vibrio cholerae O37 strain ATCC 25872

Toxin (Protein)


Gene name relE Uniprot ID A0A0H3AD26
Locus tag GTH07_RS15255 Protein ID WP_000807826.1
Coordinates 381874..382176 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag GTH07_RS15250 Protein ID WP_000861987.1
Coordinates 381629..381886 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTH07_RS15220 (GTH07_15280) 376985..377677 + 693 WP_000780703.1 hypothetical protein -
GTH07_RS15225 (GTH07_15285) 377677..378237 + 561 WP_000440232.1 hypothetical protein -
GTH07_RS15235 (GTH07_15295) 379661..380023 + 363 WP_227746413.1 hypothetical protein -
GTH07_RS15240 (GTH07_15300) 380118..380543 + 426 WP_000403003.1 GNAT family N-acetyltransferase -
GTH07_RS15245 (GTH07_15305) 380787..381023 + 237 WP_001065132.1 hypothetical protein -
GTH07_RS15250 (GTH07_15310) 381629..381886 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GTH07_RS15255 (GTH07_15315) 381874..382176 + 303 WP_000807826.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GTH07_RS18670 382254..382319 + 66 Protein_391 acetyltransferase -
GTH07_RS15260 (GTH07_15320) 382339..382920 + 582 WP_001025027.1 hypothetical protein -
GTH07_RS15265 (GTH07_15325) 382911..383027 + 117 WP_114732087.1 DUF3265 domain-containing protein -
GTH07_RS15270 (GTH07_15330) 383017..383169 + 153 Protein_394 DUF3709 domain-containing protein -
GTH07_RS15275 (GTH07_15335) 383190..383411 + 222 WP_032074688.1 DUF3709 domain-containing protein -
GTH07_RS18675 383612..383713 + 102 WP_080484623.1 acetyltransferase -
GTH07_RS15280 (GTH07_15340) 383676..384113 + 438 WP_012706054.1 hypothetical protein -
GTH07_RS15285 (GTH07_15345) 384262..385188 + 927 WP_000377815.1 hypothetical protein -
GTH07_RS15290 (GTH07_15350) 385328..385714 + 387 WP_001015083.1 MmcQ/YjbR family DNA-binding protein -
GTH07_RS15295 (GTH07_15355) 385898..386221 + 324 WP_001999495.1 DUF3709 domain-containing protein -
GTH07_RS15300 (GTH07_15360) 386507..386902 + 396 WP_000870868.1 DUF3465 domain-containing protein -
GTH07_RS18680 (GTH07_15365) 386969..387083 + 115 Protein_402 acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 307620..433724 126104
- inside Integron - - 312700..433348 120648


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11725.65 Da        Isoelectric Point: 5.1972

>T145909 WP_000807826.1 NZ_CP047306:381874-382176 [Vibrio cholerae O37]
MAEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPLELEHLNYREVVVNPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T145909 NZ_CP062708:c3587490-3587335 [Escherichia coli O157:H7]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAGTCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT145909 WP_000861987.1 NZ_CP047306:381629-381886 [Vibrio cholerae O37]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT145909 NZ_CP062708:3587502-3587560 [Escherichia coli O157:H7]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3AD26

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SLM9

References