Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 374453..375018 Replicon chromosome
Accession NZ_CP047306
Organism Vibrio cholerae O37 strain ATCC 25872

Toxin (Protein)


Gene name relE Uniprot ID D7HCW8
Locus tag GTH07_RS15200 Protein ID WP_000869999.1
Coordinates 374731..375018 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D0IIK3
Locus tag GTH07_RS15195 Protein ID WP_000086649.1
Coordinates 374453..374734 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTH07_RS15160 (GTH07_15220) 369575..369934 + 360 WP_001071514.1 VOC family protein -
GTH07_RS15165 (GTH07_15225) 370117..370440 + 324 WP_001889156.1 DUF3709 domain-containing protein -
GTH07_RS15170 (GTH07_15230) 370721..371257 + 537 WP_000469482.1 GNAT family protein -
GTH07_RS18660 371780..371903 + 124 Protein_372 acetyltransferase -
GTH07_RS15175 (GTH07_15235) 372018..372200 + 183 WP_000947517.1 DUF645 family protein -
GTH07_RS15180 (GTH07_15240) 372319..373104 + 786 WP_001176447.1 hypothetical protein -
GTH07_RS15185 (GTH07_15245) 373254..373568 + 315 WP_000248694.1 DUF4144 domain-containing protein -
GTH07_RS18665 373650..373778 + 129 WP_001894944.1 hypothetical protein -
GTH07_RS15190 (GTH07_15250) 373814..374239 + 426 WP_000735184.1 hypothetical protein -
GTH07_RS15195 (GTH07_15255) 374453..374734 + 282 WP_000086649.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GTH07_RS15200 (GTH07_15260) 374731..375018 + 288 WP_000869999.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GTH07_RS15205 (GTH07_15265) 375177..375716 + 540 WP_000884561.1 hydrolase -
GTH07_RS15210 (GTH07_15270) 375872..376300 + 429 WP_002034862.1 hypothetical protein -
GTH07_RS15215 (GTH07_15275) 376595..376777 + 183 WP_001889223.1 DUF645 family protein -
GTH07_RS15220 (GTH07_15280) 376985..377677 + 693 WP_000780703.1 hypothetical protein -
GTH07_RS15225 (GTH07_15285) 377677..378237 + 561 WP_000440232.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 307620..433724 126104
- inside Integron - - 312700..433348 120648


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-74)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10997.74 Da        Isoelectric Point: 6.0710

>T145908 WP_000869999.1 NZ_CP047306:374731-375018 [Vibrio cholerae O37]
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQLLTEHDV

Download         Length: 288 bp

>T145908 NZ_CP062708:c3371427-3371053 [Escherichia coli O157:H7]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10361.93 Da        Isoelectric Point: 5.1548

>AT145908 WP_000086649.1 NZ_CP047306:374453-374734 [Vibrio cholerae O37]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK

Download         Length: 282 bp

>AT145908 NZ_CP062708:c3371848-3371474 [Escherichia coli O157:H7]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3AEF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0K9UIW4

References