Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 361024..361562 Replicon chromosome
Accession NZ_CP047306
Organism Vibrio cholerae O37 strain ATCC 25872

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag GTH07_RS15090 Protein ID WP_000802136.1
Coordinates 361024..361323 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag GTH07_RS15095 Protein ID WP_001107719.1
Coordinates 361320..361562 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTH07_RS15055 (GTH07_15105) 356531..356890 + 360 WP_001071529.1 VOC family protein -
GTH07_RS15060 (GTH07_15110) 357037..357690 + 654 WP_000895163.1 hypothetical protein -
GTH07_RS15070 (GTH07_15120) 358239..358922 + 684 WP_000877436.1 hypothetical protein -
GTH07_RS15075 (GTH07_15125) 359136..359402 + 267 WP_000937852.1 hypothetical protein -
GTH07_RS15080 (GTH07_15130) 360108..360287 + 180 WP_001883058.1 DUF645 family protein -
GTH07_RS15085 (GTH07_15135) 360501..360896 + 396 WP_000870857.1 DUF3465 domain-containing protein -
GTH07_RS15090 (GTH07_15140) 361024..361323 - 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GTH07_RS15095 (GTH07_15145) 361320..361562 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
GTH07_RS15100 (GTH07_15150) 361791..362369 + 579 WP_000110120.1 hypothetical protein -
GTH07_RS15105 (GTH07_15155) 362391..362483 + 93 WP_014164112.1 DUF3265 domain-containing protein -
GTH07_RS18640 362757..362879 + 123 WP_228840823.1 DUF3709 domain-containing protein -
GTH07_RS15115 (GTH07_15165) 363158..363436 + 279 WP_001012254.1 hypothetical protein -
GTH07_RS18645 (GTH07_15170) 363495..363620 + 126 WP_088126107.1 DUF3265 domain-containing protein -
GTH07_RS15120 (GTH07_15175) 363701..364162 + 462 Protein_360 lipocalin family protein -
GTH07_RS18650 364227..364307 + 81 Protein_361 acetyltransferase -
GTH07_RS15125 (GTH07_15180) 364310..364606 + 297 WP_000617998.1 Dabb family protein -
GTH07_RS15130 (GTH07_15190) 365745..366371 + 627 WP_001889198.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 307620..433724 126104
- inside Integron - - 312700..433348 120648


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T145907 WP_000802136.1 NZ_CP047306:c361323-361024 [Vibrio cholerae O37]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T145907 NZ_CP062708:3115103-3115210 [Escherichia coli O157:H7]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT145907 WP_001107719.1 NZ_CP047306:c361562-361320 [Vibrio cholerae O37]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT145907 NZ_CP062708:c3115050-3114989 [Escherichia coli O157:H7]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
PDB 7R5A
PDB 7B22
AlphaFold DB A0A151JFU4

References