Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 337268..337766 Replicon chromosome
Accession NZ_CP047306
Organism Vibrio cholerae O37 strain ATCC 25872

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag GTH07_RS14885 Protein ID WP_000589156.1
Coordinates 337268..337534 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag GTH07_RS14890 Protein ID WP_000643598.1
Coordinates 337521..337766 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTH07_RS14840 (GTH07_14870) 332373..332837 + 465 WP_000041933.1 hypothetical protein -
GTH07_RS14845 (GTH07_14875) 333068..333493 + 426 WP_001890147.1 hypothetical protein -
GTH07_RS14850 (GTH07_14880) 333646..334020 + 375 WP_000331785.1 hypothetical protein -
GTH07_RS14855 (GTH07_14885) 334232..334474 + 243 WP_000107461.1 hypothetical protein -
GTH07_RS14860 (GTH07_14890) 334726..335004 + 279 WP_000280324.1 DUF3709 domain-containing protein -
GTH07_RS18590 335436..335479 + 44 Protein_302 hypothetical protein -
GTH07_RS18595 335461..335554 + 94 Protein_303 ggdef family protein -
GTH07_RS18600 335523..335654 + 132 WP_001883067.1 hypothetical protein -
GTH07_RS14875 (GTH07_14905) 335826..336293 + 468 WP_001289288.1 OsmC family protein -
GTH07_RS14880 (GTH07_14910) 336421..337083 + 663 WP_000960654.1 hypothetical protein -
GTH07_RS18605 (GTH07_14915) 337073..337201 + 129 WP_088124358.1 DUF3265 domain-containing protein -
GTH07_RS14885 (GTH07_14920) 337268..337534 + 267 WP_000589156.1 BrnT family toxin Toxin
GTH07_RS14890 (GTH07_14925) 337521..337766 + 246 WP_000643598.1 hypothetical protein Antitoxin
GTH07_RS14895 (GTH07_14930) 337862..338656 + 795 WP_001911581.1 hypothetical protein -
GTH07_RS18610 (GTH07_14935) 338653..338769 + 117 WP_086010881.1 DUF3265 domain-containing protein -
GTH07_RS14900 (GTH07_14940) 338759..338887 + 129 WP_071908338.1 general secretion pathway protein GspI -
GTH07_RS14905 (GTH07_14945) 338948..339130 + 183 WP_000923182.1 DUF645 family protein -
GTH07_RS14910 (GTH07_14950) 339346..340350 + 1005 WP_000964920.1 LD-carboxypeptidase -
GTH07_RS14915 (GTH07_14955) 340503..340862 + 360 WP_001071541.1 VOC family protein -
GTH07_RS18615 340929..341114 + 186 WP_001999468.1 hypothetical protein -
GTH07_RS18620 341246..341368 + 123 WP_001937972.1 DUF3709 domain-containing protein -
GTH07_RS14925 (GTH07_14965) 341636..342142 + 507 WP_000393074.1 hypothetical protein -
GTH07_RS14930 (GTH07_14970) 342299..342685 + 387 WP_000703163.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 307620..433724 126104
- inside Integron - - 312700..433348 120648


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T145905 WP_000589156.1 NZ_CP047306:337268-337534 [Vibrio cholerae O37]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T145905 NZ_CP062708:3066560-3066838 [Escherichia coli O157:H7]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT145905 WP_000643598.1 NZ_CP047306:337521-337766 [Vibrio cholerae O37]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT145905 NZ_CP062708:3066367-3066558 [Escherichia coli O157:H7]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A271VMP7

Antitoxin

Source ID Structure
AlphaFold DB A0A271VME2

References