Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/YafN(antitoxin) |
| Location | 321711..322276 | Replicon | chromosome |
| Accession | NZ_CP047306 | ||
| Organism | Vibrio cholerae O37 strain ATCC 25872 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A5C9T169 |
| Locus tag | GTH07_RS14750 | Protein ID | WP_000869993.1 |
| Coordinates | 321989..322276 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | GTH07_RS14745 | Protein ID | WP_000086651.1 |
| Coordinates | 321711..321992 (+) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GTH07_RS14710 (GTH07_14725) | 317109..317606 | - | 498 | WP_000982260.1 | GNAT family N-acetyltransferase | - |
| GTH07_RS14715 (GTH07_14730) | 317603..317875 | - | 273 | WP_000246253.1 | DUF1778 domain-containing protein | - |
| GTH07_RS14720 (GTH07_14735) | 318267..318446 | + | 180 | WP_001883058.1 | DUF645 family protein | - |
| GTH07_RS14725 (GTH07_14740) | 318671..319783 | + | 1113 | WP_212563483.1 | AAA family ATPase | - |
| GTH07_RS14730 (GTH07_14745) | 319788..320450 | + | 663 | WP_001064760.1 | RelA/SpoT domain-containing protein | - |
| GTH07_RS14735 (GTH07_14750) | 320620..320973 | + | 354 | WP_000384364.1 | DUF6404 family protein | - |
| GTH07_RS14740 (GTH07_14755) | 321125..321511 | + | 387 | WP_001015080.1 | MmcQ/YjbR family DNA-binding protein | - |
| GTH07_RS14745 (GTH07_14760) | 321711..321992 | + | 282 | WP_000086651.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| GTH07_RS14750 (GTH07_14765) | 321989..322276 | + | 288 | WP_000869993.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| GTH07_RS14760 (GTH07_14775) | 322439..323272 | + | 834 | WP_000575667.1 | EcsC family protein | - |
| GTH07_RS14765 (GTH07_14780) | 323435..324205 | + | 771 | WP_000797381.1 | alpha/beta hydrolase | - |
| GTH07_RS18570 | 324272..324457 | + | 186 | WP_102981787.1 | disulfide bond formation protein DsbD | - |
| GTH07_RS14770 (GTH07_14785) | 324475..324711 | + | 237 | WP_172776555.1 | DUF3709 domain-containing protein | - |
| GTH07_RS14775 (GTH07_14790) | 325139..325321 | + | 183 | WP_059443366.1 | DUF645 family protein | - |
| GTH07_RS14780 (GTH07_14795) | 325518..325973 | + | 456 | WP_025818898.1 | hypothetical protein | - |
| GTH07_RS14785 (GTH07_14800) | 325988..326080 | + | 93 | WP_193791190.1 | DUF3265 domain-containing protein | - |
| GTH07_RS14790 (GTH07_14805) | 326117..326569 | + | 453 | WP_000863107.1 | GNAT family N-acetyltransferase | - |
| GTH07_RS14795 (GTH07_14810) | 326560..326676 | + | 117 | WP_102981790.1 | DUF3265 domain-containing protein | - |
| GTH07_RS14800 (GTH07_14815) | 326763..327242 | + | 480 | WP_000009888.1 | lecithin retinol acyltransferase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 307620..433724 | 126104 | |
| - | inside | Integron | - | - | 312700..433348 | 120648 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 10915.68 Da Isoelectric Point: 5.6023
>T145904 WP_000869993.1 NZ_CP047306:321989-322276 [Vibrio cholerae O37]
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNDVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLGLEIRV
LTVRNCRQLLSEHDV
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNDVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLGLEIRV
LTVRNCRQLLSEHDV
Download Length: 288 bp
>T145904 NZ_CP062708:c2856668-2856492 [Escherichia coli O157:H7]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA
Antitoxin
Download Length: 94 a.a. Molecular weight: 10346.92 Da Isoelectric Point: 5.8598
>AT145904 WP_000086651.1 NZ_CP047306:321711-321992 [Vibrio cholerae O37]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGVSN
ENARSQVLGRIIK
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGVSN
ENARSQVLGRIIK
Download Length: 282 bp
>AT145904 NZ_CP062708:c2856446-2856030 [Escherichia coli O157:H7]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAAGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCAGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAAGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCAGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|