Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2207093..2208918 Replicon chromosome
Accession NZ_CP047299
Organism Vibrio cholerae O1 biovar El Tor strain P27459

Toxin (Protein)


Gene name hipA Uniprot ID A0A0K9UVP8
Locus tag GTF71_RS09925 Protein ID WP_000392003.1
Coordinates 2207093..2208454 (+) Length 454 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag GTF71_RS09930 Protein ID WP_000804849.1
Coordinates 2208451..2208918 (+) Length 156 a.a.

Genomic Context

GTF71_RS09910GTF71_RS09915GTF71_RS09925GTF71_RS09930GTF71_RS09935GTF71_RS09940GTF71_RS09945GTF71_RS09920
Location: 2202944..2204464 (1521 bp)
Type: Others
Protein ID: WP_000640055.1
Location: 2204806..2205486 (681 bp)
Type: Others
Protein ID: Protein_1927
Location: 2207093..2208454 (1362 bp)
Type: Toxin
Protein ID: WP_000392003.1
Location: 2208451..2208918 (468 bp)
Type: Antitoxin
Protein ID: WP_000804849.1
Location: 2209346..2209924 (579 bp)
Type: Others
Protein ID: WP_000109982.1
Location: 2209928..2212864 (2937 bp)
Type: Others
Protein ID: WP_001283872.1
Location: 2212934..2213638 (705 bp)
Type: Others
Protein ID: WP_001880605.1
Location: 2205512..2206489 (978 bp)
Type: Others
Protein ID: WP_001889101.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GTF71_RS099102202944..2204464+1521WP_000640055.1aldehyde dehydrogenase-
GTF71_RS099152204806..2205486+681Protein_1927IS5 family transposase-
GTF71_RS099202205512..2206489-978WP_001889101.1IS481-like element ISVch1 family transposase-
GTF71_RS099252207093..2208454+1362WP_000392003.1type II toxin-antitoxin system HipA family toxinToxin
GTF71_RS099302208451..2208918+468WP_000804849.1helix-turn-helix domain-containing proteinAntitoxin
GTF71_RS099352209346..2209924+579WP_000109982.1class I SAM-dependent methyltransferase-
GTF71_RS099402209928..2212864+2937WP_001283872.1DEAD/DEAH box helicase family protein-
GTF71_RS099452212934..2213638+705WP_001880605.1NERD domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-383)

Antitoxin

Cro/C1-type helix-turn-helix domain

(80-138)


Sequences

Toxin        


Download         Length: 454 a.a.        Molecular weight: 51246.17 Da        Isoelectric Point: 4.9109

>T145842 WP_000392003.1 NZ_CP047299:2207093-2208454 [Vibrio cholerae O1 biovar El Tor]
MEELTVQAFIRGEWIDIGIISFPKSSQHNFRVTELNYLSDYALEHYDKDDFHAVSLNHPVSFIFDDMGKPGWLKFLDDIM
PSGASRRYWVKHLDIEDLSSDEQDYVLLKFGTMSPIGNLRIKDSLPERYEVADNLYFSVDDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLILRCGFDHGSGSEKIWIDPYQDDNSSHDLHYLVKYPRGSRSTIDCNILRAEFYFYHELTEMGVETIS
TDGMRLEEGLNYPSLWLPRFDVQIIDQQIERFGMESVYSILNKGAGVTLDHETTIRTLIEKITESNMVKHQGYRFDTQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPIYDFAPMKADPAGIPRTTKWKAPLEVGGTYDFVGIADTLSDLV
PKEMLLKELAITASKCVGLKQRLALRGVPEQILEMPAVGLNYLSEKLTKWGLL

Download         Length: 1362 bp

>T145842 NZ_CP062702:2622444-2622599 [Escherichia coli O157:H7]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTGCGAATCCGAACCGGTCAGACGGAGGTCGCTGTCTTCGTAGACTACGAATCTGAGAAGTAA

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 17095.51 Da        Isoelectric Point: 10.6157

>AT145842 WP_000804849.1 NZ_CP047299:2208451-2208918 [Vibrio cholerae O1 biovar El Tor]
MKPSNKESVQDTVARLRENRNQQQSKVGKNATHSSKEQTPLDTPTRSKASKNAKAVSAAERKTEANKIIKHLLLGELTQG
QALKSLRINILGLKQDVFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFSLKIGLLPSSPDALKSLLMDGEDG

Download         Length: 468 bp

>AT145842 NZ_CP062702:c2622432-2622374 [Escherichia coli O157:H7]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0K9UVP8

Antitoxin

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Source
ID
Structure
No matching records found

References